SynthesisInternal and emergency medicine2020
Serum albumin and risk of cardiovascular events in primary and secondary prevention: a systematic review of observational studies and Bayesian meta-regression analysis.
Synthesis in Internal and emergency medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 43 citations in OpenAlex.
- The relationship between fibrinogen-to-albumin ratio and brachial-ankle pulse wave velocity in elderly individuals in China: a cross-sectional study.Frontiers in cardiovascular medicine · 2026Article
- Early Supplementation with Branched-Chain Amino Acids Ameliorates Lipid Retention in Aortic Valves of ApoE-Knockout Mice.International journal of molecular sciences · 2025Article
- Machine learning-based models to predict type 2 diabetes combined with coronary heart disease and feature analysis-based on interpretable SHAP.Acta diabetologica · 2025Article
- Serum albumin combined with high-density lipoprotein cholesterol as a novel marker to predict coronary heart disease: are their associations multiplicative or rateable?Frontiers in cardiovascular medicine · 2025Article
- Elevated Uric Acid/Albumin Ratio Predicts Poor Coronary Collateral Circulation in Type 2 Diabetic Patients With Stable Coronary Artery Disease.Journal of diabetes research · 2025Article
- Functional and prognostic impacts of serum albumin with thoracic arterial calcification among asymptomatic individuals.Scientific reports · 2024Article
- Article
- Machine learning-based models to predict one-year mortality among Chinese older patients with coronary artery disease combined with impaired glucose tolerance or diabetes mellitus.Cardiovascular diabetology · 2023Article
- A nomogram diagnostic cardiovascular disease in patients with erythrodermic psoriasis in Chinese.Frontiers in immunology · 2023Article
- Calciprotein Particles Cause Physiologically Significant Pro-Inflammatory Response in Endothelial Cells and Systemic Circulation.International journal of molecular sciences · 2022Article
- Experimental and Computational Investigation on the Interaction of Anticancer Drug Gemcitabine with Human Plasma Protein: Effect of Copresence of Ibuprofen on the Binding.Molecules (Basel, Switzerland) · 2022Article
- Protein Nutritional Status and Frailty: A Mendelian Randomization Study.The Journal of nutrition · 2022Article
- Artificial Intelligence-Enabled Electrocardiography Detects Hypoalbuminemia and Identifies the Mechanism of Hepatorenal and Cardiovascular Events.Frontiers in cardiovascular medicine · 2022Article
- Oxidative stress mediated platelet activation in patients with congenital analbuminemia: Effect of albumin infusion.Journal of thrombosis and haemostasis : JTH · 2021Article
- Impaired Clinical Efficacy of Aspirin in Hypoalbuminemic Patients With Diabetes Mellitus.Frontiers in pharmacology · 2021Article
- Article
- Oxidative Modifications in Advanced Atherosclerotic Plaques: A Focus onOxidative medicine and cellular longevity · 2020Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The predictive role of serum albumin (SA) has been evaluated in primary prevention studies. We want to assess the association of SA with the subsequent risk of cardiovascular events (CVE) in primary and secondary prevention studies. We performed a systematic review and Bayesian meta-regression analysis. Studies were identified by PubMed and EMBASE database using a combination of the following terms and MeSH terms: "serum albumin", "myocardial infarction, "cardiovascular events", "percutaneous coronary intervention" and "coronary restenosis". No time restriction of the research was applied. Two experienced physicians reviewed data on outcome measures and assessed the quality rating. The main outcomes were CVE including myocardial infarction, coronary heart disease, percutaneous coronary intervention and coronary restenosis. 15 studies of SA and CVE were identified involving 65,077 subjects with a mean age of 57.89 ± 6.05 years and a mean follow-up of 9.4 (±5.56) years. Subjects under SA cut-off of 3.8 g/dL had a combined hazard ratio (HR) for CVE of 2.16 [95% confidence interval (CI) 1.93-2.45]. An increased risk for CVE was also evident using SA as a continuous variable (HR = 1.89, 95% CI 1.5-2.39). Females and males had a similar risk for CVE (HR 2.46, 95% CI 1.92-3.16, and HR 1.46, 95% CI 1.27-1.69, respectively). We found a similar risk of CVE between primary and secondary prevention studies (HR 1.79, 95% CI 1.5-2.17, and HR 2.47, 95% CI 2.24-2.75, respectively). Low SA levels are associated with an increased risk of CVE, not only in subjects free from CVE, but also in patients who already experienced a CVE.
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