Evidence map›Paper›PMID 31604983›Full record

ArticleScientific reports2019

In vitro nephrotoxicity and anticancer potency of newly synthesized cadmium complexes.

Selda Abyar, Ali Akbar Khandar, Roya Salehi, Seyed Abolfazl Hosseini-Yazdi, Effat Alizadeh, Mehrdad Mahkam, Amer Jamalpoor, Jonathan M White, Motahhareh Shojaei, O Aizpurua-Olaizola and 2 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 40 citations in OpenAlex.

  1. Biological effects of p-PYA ligands on certain trace elements of group-12 towards DNA binding and cytotoxicity potency.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
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  8. Co(II) complexes of curcumin and a ferrocene-based curcuminoid: a study on photo-induced antitumor activity.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Selda AbyarDepartment of Inorganic Chemistry, Faculty of Chemistry, University of Tabriz, Tabriz, 5166614766, Iran.
Ali Akbar KhandarDepartment of Inorganic Chemistry, Faculty of Chemistry, University of Tabriz, Tabriz, 5166614766, Iran. akhandar@yahoo.com.
Roya SalehiDrug Applied Research Center and Department of Medical Nanotechnology, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences, Tabriz, 51656-65811, Iran. roya.salehi@gmail.com.
Seyed Abolfazl Hosseini-YazdiDepartment of Inorganic Chemistry, Faculty of Chemistry, University of Tabriz, Tabriz, 5166614766, Iran.
Effat AlizadehDrug Applied Research Center and Department of Medical Nanotechnology, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences, Tabriz, 51656-65811, Iran.
Mehrdad MahkamChemistry Department, Faculty of Science, Azerbaijan Shahid Madani University, Tabriz, 5375171379, Iran.
Amer JamalpoorDivision of pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, 3584 CG, Utrecht, Netherlands.
Jonathan M WhiteSchool of Chemistry and BIO-21 Institute, University of Melbourne, Parkville, Vic., 3010, Australia.
Motahhareh ShojaeiDepartment of Inorganic Chemistry, Faculty of Chemistry, University of Tabriz, Tabriz, 5166614766, Iran.
O Aizpurua-OlaizolaDepartment of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, Utrecht, Netherlands.
Rosalinde MasereeuwDivision of pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, 3584 CG, Utrecht, Netherlands.ORCID http://orcid.org/0000-0002-1560-1074
Manoe J JanssenDivision of pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, 3584 CG, Utrecht, Netherlands. m.j.janssen1@uu.nl.ORCID http://orcid.org/0000-0002-0544-8096
Utrecht University · NLUniversity of Tabriz · IRTabriz University of Medical Sciences · IRAzarbaijan Shahid Madani University · IRThe University of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Complexes based on heavy metals have great potential for the treatment of a wide variety of cancers but their use is often limited due to toxic side effects. Here we describe the synthesis of two new cadmium complexes using N(4)-phenyl-2-formylpyridine thiosemicarbazone (L1) and 5-aminotetrazole (L2) as organic ligands and the evaluation of their anti-cancer and nephrotoxic potential in vitro. The complexes were characterized by Single-crystal X-ray data diffraction,

Indexed as

A549 CellsAntineoplastic AgentsApoptosisCadmiumCell CycleCisplatinCoordination ComplexesHumansKidneyLigandsMCF-7 CellsNeoplasmsSpectroscopy, Fourier Transform InfraredTetrazolesThiosemicarbazones5-amino-1H-tetrazoleAntineoplastic AgentsCadmiumCisplatinCoordination ComplexesLigandsTetrazolesThiosemicarbazones

Identifiers

PMID31604983
PMCPMC6789105
OpenAlexW2980180444

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.