ArticleScientific reports2019
Quantitative Histopathology of Stained Tissues using Color Spatial Light Interference Microscopy (cSLIM).
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.
- The association between tumor-stromal collagen features and the clinical outcomes of patients with breast cancer: a systematic review.Breast cancer research : BCR · 2025Pooled it
- Label-free volumetric refractive-index imaging of fibrillar collagen architecture, assembly, and cell-associated remodeling.bioRxiv : the preprint server for biology · 2026Article
- Histopathological Picture of Lung Organs Towards Combination of Java Cardamom Seed Extract and Turmeric Rhizome as Anti-Colibacillosis in Broiler Chickens.Veterinary sciences · 2025Article
- Full-Field Assessment of Geometry and Collagenous Architecture of Porcine Valve Leaflets via Laser Micrometry and Quantitative Polarized Light Imaging.Journal of biophotonics · 2025Article
- Thiacloprid impairs reproductive functions of male Wistar rats.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Quantitative phase imaging techniques for measuring scattering properties of cells and tissues: a review-part I.Journal of biomedical optics · 2024Review
- Towards ultrafast quantitative phase imaging via differentiable microscopy [Invited].Biomedical optics express · 2024Article
- Roadmap on Label-Free Super-Resolution Imaging.Laser & photonics reviews · 2023Article
- Digital staining facilitates biomedical microscopy.Frontiers in bioinformatics · 2023Article
- White blood cell detection, classification and analysis using phase imaging with computational specificity (PICS).Scientific reports · 2022Article
- Automatic Colorectal Cancer Screening Using Deep Learning in Spatial Light Interference Microscopy Data.Cells · 2022Article
- Monitoring reactivation of latent HIV by label-free gradient light interference microscopy.iScience · 2021Article
- Label-free screening of brain tissue myelin content using phase imaging with computational specificity (PICS).APL photonics · 2021Article
- Spatial light interference microscopy: principle and applications to biomedicine.Advances in optics and photonics · 2021Article
- Computational interference microscopy enabled by deep learning.APL photonics · 2021Article
- Application of Fast Non-Local Means Algorithm for Noise Reduction Using Separable Color Channels in Light Microscopy Images.International journal of environmental research and public health · 2021Article
- Real-time Jones phase microscopy for studying transparent and birefringent specimens.Optics express · 2020Article
- Reproductive outcomes predicted by phase imaging with computational specificity of spermatozoon ultrastructure.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Label-free colorectal cancer screening using deep learning and spatial light interference microscopy (SLIM).APL photonics · 2020Article
- Tumor-associated collagen signatures: pushing tumor boundaries.Cancer & metabolism · 2020Review
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
Tissue biopsy evaluation in the clinic is in need of quantitative disease markers for diagnosis and, most importantly, prognosis. Among the new technologies, quantitative phase imaging (QPI) has demonstrated promise for histopathology because it reveals intrinsic tissue nanoarchitecture through the refractive index. However, a vast majority of past QPI investigations have relied on imaging unstained tissues, which disrupts the established specimen processing. Here we present color spatial light interference microscopy (cSLIM) as a new whole-slide imaging modality that performs interferometric imaging on stained tissue, with a color detector array. As a result, cSLIM yields in a single scan both the intrinsic tissue phase map and the standard color bright-field image, familiar to the pathologist. Our results on 196 breast cancer patients indicate that cSLIM can provide stain-independent prognostic information from the alignment of collagen fibers in the tumor microenvironment. The effects of staining on the tissue phase maps were corrected by a mathematical normalization. These characteristics are likely to reduce barriers to clinical translation for the new cSLIM technology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.