ArticleNature communications2019
A chemically fueled non-enzymatic bistable network.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Light-Driven Competitive Selection in a Protein-Catalyzed Dissipative Peptide Replication.Angewandte Chemie (International ed. in English) · 2026Article
- Continuously tunable multistability in DNA replication networks.Nature communications · 2026Article
- Designing Catalysts to Accelerate a Protein-Peptide Assembly-Reaction Cascade.ACS central science · 2025Article
- Article
- Bistable Functions and Signaling Motifs in Systems Chemistry: Taking the Next Step Toward Synthetic Cells.Accounts of chemical research · 2025Review
- Non-equilibrium self-assembly for living matter-like properties.Nature reviews. Chemistry · 2024Review
- Exploring the programmability of autocatalytic chemical reaction networks.Nature communications · 2024Article
- Physical Chemistry Models for Chemical Research in the XXth and XXIst Centuries.ACS physical chemistry Au · 2024Review
- Multistable Protocells Can Aid the Evolution of Prebiotic Autocatalytic Sets.Life (Basel, Switzerland) · 2023Article
- The protometabolic nature of prebiotic chemistry.Chemical Society reviews · 2023Review
- Dynamics of hydroxide-ion-driven reversible autocatalytic networks.RSC advances · 2023Article
- Light-Fueled Primitive Replication and Selection in Biomimetic Chemical Systems.Journal of the American Chemical Society · 2023Article
- Collective adaptability in a replication network of minimal nucleobase sequences.Chemical science · 2022Article
- Memory, switches, and an OR-port through bistability in chemically fueled crystals.Nature communications · 2022Article
- Out-of-Equilibrium Self-Replication Allows Selection for Dynamic Kinetic Stability in a System of Competing Replicators.Angewandte Chemie (International ed. in English) · 2022Article
- A robust method for designing multistable systems by embedding bistable subsystems.NPJ systems biology and applications · 2022Article
- An Approach to the De Novo Synthesis of Life.Accounts of chemical research · 2022Article
- Feedback and Communication in Active Hydrogel Spheres with pH Fronts: Facile Approaches to Grow Soft Hydrogel Structures.Angewandte Chemie (International ed. in English) · 2021Article
- Chemical Fueling Enables Molecular Complexification of Self-Replicators*.Angewandte Chemie (International ed. in English) · 2021Article
- Self-Reproduction and Darwinian Evolution in Autocatalytic Chemical Reaction Systems.Life (Basel, Switzerland) · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One of the grand challenges in contemporary systems chemistry research is to mimic life-like functions using simple synthetic molecular networks. This is particularly true for systems that are out of chemical equilibrium and show complex dynamic behaviour, such as multi-stability, oscillations and chaos. We report here on thiodepsipeptide-based non-enzymatic networks propelled by reversible replication processes out of equilibrium, displaying bistability. Accordingly, we present quantitative analyses of the bistable behaviour, featuring a phase transition from the simple equilibration processes taking place in reversible dynamic chemistry into the bistable region. This behaviour is observed only when the system is continuously fueled by a reducing agent that keeps it far from equilibrium, and only when operating within a specifically defined parameter space. We propose that the development of biomimetic bistable systems will pave the way towards the study of more elaborate functions, such as information transfer and signalling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.