ArticleNature communications2019
High-potency ligands for DREADD imaging and activation in rodents and monkeys.
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Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers.
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131citing papers in PubMed
10.3field-weighted citation impact, top 1% of its field
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Who cites it
131 citing papers in PubMed, 211 citations in OpenAlex.
- Overview of the DREADDs chemogenetics and the patent landscape of their actuators.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026Review
- Off-target effects of DREADD ligands revealed by an anesthesia emergence paradigm in mice.Cell reports methods · 2026Article
- Interrogating roles for VTA dopamine neurons in locomotion and ultrasonic vocalizations elicited by different classes of rewarding drugs.Psychopharmacology · 2026Article
- Next-generation chemogenetic inhibition using a brain-permeant non-prescription agent.Signal transduction and targeted therapy · 2026Article
- Ovarian hormonal state at exercise initiation interacts with nigrostriatal circuitry to determine long-term voluntary exercise behavior.bioRxiv : the preprint server for biology · 2026Article
- Noninvasive focal gene transfer of chemogenetic proteins in the primate brain.Cell reports methods · 2026Article
- Synthetic serum markers enable noninvasive monitoring of gene expression in primate brains.Neuron · 2026Article
- Dentate gyrus and CA3 activity mediates light-tone second-order conditioning expression in mice.iScience · 2026Article
- Chemogenetic modulation of the prelimbic cortex to the nucleus accumbens core pathway reduces cocaine-induced increase of risk preference.Translational psychiatry · 2026Article
- High-throughput assessment of vocal modulation following chemogenetic inhibition in songbirds.iScience · 2026Article
- Integrating living biomaterials into neuroelectronic systems.Biomedical engineering letters · 2026Review
- Glutamatergic dysfunction of astrocytes in paraventricular nucleus of thalamus contributes to adult anxiety susceptibility in adolescent ethanol exposed mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Persistent representation of a prior schema in the orbitofrontal cortex facilitates learning of a conflicting schema.Nature communications · 2026Article
- Ventral pallidal perineuronal nets regulate opioid relapse.bioRxiv : the preprint server for biology · 2026Article
- Genetic manipulation technologies for precise cellular control: a comparative review of five approaches.Frontiers in bioengineering and biotechnology · 2026Review
- Engineering of rhesus monkey pluripotent stem cells for noninvasive survey and remote control after brain allotransplantation.Fundamental research · 2026Article
- Advances in chemogenetics: a review of DREADDs and its application in psychiatric disorders.Molecular psychiatry · 2026Review
- Antecedent hypoglycaemia impairs glucagon secretion by enhancing somatostatin-mediated negative feedback control.Nature metabolism · 2026Article
- Medial entorhinal VIP-expressing interneurons receive input from the thalamic anterior dorsal nucleus and are critical for spatial memory.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Spatially heterogeneous acetylcholine dynamics in the striatum promote behavioral flexibility.Nature communications · 2025Article
71 more citing papers are in PubMed but not listed here.
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Authors and funding
25 authors at 9 institutions in 4 countries.
Jordi BonaventuraBiobehavioral Imaging and Molecular Neuropsychopharmacology Unit, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, 21224, USA.ORCID http://orcid.org/0000-0002-4745-0151
Mark A G EldridgeLaboratory of Neuropsychology, National Institute of Mental Health Intramural Research Program, Bethesda, MD, 20892, USA.ORCID http://orcid.org/0000-0003-4292-6832
Feng HuDepartment of Radiology Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA.ORCID http://orcid.org/0000-0003-4176-5694
Juan L GomezBiobehavioral Imaging and Molecular Neuropsychopharmacology Unit, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, 21224, USA.
Marta Sanchez-SotoMolecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke Intramural Research Program, Bethesda, MD, 20814, USA.
Ara M AbramyanComputational Chemistry and Molecular Biophysics Unit, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, 21224, USA.
Sherry LamBiobehavioral Imaging and Molecular Neuropsychopharmacology Unit, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, 21224, USA.
Matthew A BoehmBiobehavioral Imaging and Molecular Neuropsychopharmacology Unit, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, 21224, USA.
Christina RuizDepartment of Neurobiology & Behavior, University of California, Irvine, CA, 92697, USA.
Mitchell R FarrellDepartment of Neurobiology & Behavior, University of California, Irvine, CA, 92697, USA.
Andrea MorenoDepartment of Molecular Biology and Genetics, Dandrite, Aarhus University, 8000 Aarhus C, Aarhus, Denmark.
Islam Mustafa Galal FaressDepartment of Molecular Biology and Genetics, Dandrite, Aarhus University, 8000 Aarhus C, Aarhus, Denmark.
Niels AndersenDepartment of Molecular Biology and Genetics, Dandrite, Aarhus University, 8000 Aarhus C, Aarhus, Denmark.
John Y LinSchool of Medicine, College of Health and Medicine, University of Tasmania, Tasmania, TAS, 7000, Australia.ORCID http://orcid.org/0000-0002-1723-4597
Ruin MoaddelLaboratory of Clinical Investigation, National Institute on Aging Intramural Research Program, Baltimore, MD, 21224, USA.
Patrick J MorrisNational Center for Advancing Translational Sciences, Rockville, MD, 20850, USA.
Lei ShiComputational Chemistry and Molecular Biophysics Unit, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, 21224, USA.ORCID http://orcid.org/0000-0002-4137-096X
David R SibleyMolecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke Intramural Research Program, Bethesda, MD, 20814, USA.ORCID http://orcid.org/0000-0002-0624-962X
Stephen V MahlerDepartment of Neurobiology & Behavior, University of California, Irvine, CA, 92697, USA.ORCID http://orcid.org/0000-0002-8698-0905
Sadegh NabaviDepartment of Molecular Biology and Genetics, Dandrite, Aarhus University, 8000 Aarhus C, Aarhus, Denmark.
Martin G PomperDepartment of Radiology Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA.
Antonello BonciSynaptic Plasticity Section, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, 21224, USA.
Andrew G HortiDepartment of Radiology Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA. ahorti1@jhmi.edu.
Barry J RichmondLaboratory of Neuropsychology, National Institute of Mental Health Intramural Research Program, Bethesda, MD, 20892, USA. barryrichmond@mail.nih.gov.ORCID http://orcid.org/0000-0002-8234-1540
Michael MichaelidesBiobehavioral Imaging and Molecular Neuropsychopharmacology Unit, National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, 21224, USA. mike.michaelides@nih.gov.ORCID http://orcid.org/0000-0003-0398-4917
National Institute on Drug Abuse · USAarhus University · DKJohns Hopkins University · USUniversity of California, Irvine · USNational Institute of Mental Health · USNational Institute of Neurological Disorders and Stroke · USNational Center for Advancing Translational Sciences · USNational Institute on Aging · USUniversity of Tasmania · AU
Funding
PET Radiopharmaceutical SciencesZIAMH002793 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PIKE, VICTOR W · 2009 to 2025
$69.8MTranslational Evaluation Of PET RadiotracersZIAMH002795 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI INNIS, ROBERT · 2009 to 2025
$32.0MTraining/Dissemination-Resource for Molecular Imaging Agents in Precision MedicineP41EB024495 · NIBIB · UT SOUTHWESTERN MEDICAL CENTER · PI MARTIN G POMPER · 2017 to 2026
$11.8MPET imaging of soluble epoxide hydrolase (sEH) in human subjectsR21AG054802 · NIA · JOHNS HOPKINS UNIVERSITY · PI HORTI, ANDREW G, POMPER, MARTIN G · 2017 to 2018
$569kIntramural NIH HHS ZIA MH002793Intramural NIH HHS ZIA MH002795NIA NIH HHS R21 AG054802NIBIB NIH HHS P41 EB024495NIMH NIH HHS ZIA MH002793NIMH NIH HHS ZIA MH002795U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) ZIA000069
Abstract
Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are a popular chemogenetic technology for manipulation of neuronal activity in uninstrumented awake animals with potential for human applications as well. The prototypical DREADD agonist clozapine N-oxide (CNO) lacks brain entry and converts to clozapine, making it difficult to apply in basic and translational applications. Here we report the development of two novel DREADD agonists, JHU37152 and JHU37160, and the first dedicated
Indexed as
Designer DrugsAnimalsBrainClozapineFluorine RadioisotopesHaplorhiniHEK293 CellsHumansLigandsNeuroanatomical Tract-Tracing TechniquesNeuronal Tract-TracersPositron-Emission TomographyRodentiaClozapineclozapine N-oxideDesigner DrugsFluorine RadioisotopesLigandsNeuronal Tract-Tracers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.