Evidence map›Paper›PMID 31604819›Full record

ArticleThe Journal of biological chemistry2019

Characterization of the internal translation initiation region in monoclonal antibodies expressed in

Erik M Leith, William B O'Dell, Na Ke, Colleen McClung, Mehmet Berkmen, Christina Bergonzo, Robert G Brinson, Zvi Kelman

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Erik M LeithBiomolecular Labeling Laboratory, National Institute of Standards and Technology and Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland 20850.
William B O'DellBiomolecular Labeling Laboratory, National Institute of Standards and Technology and Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland 20850; National Institute of Standards and Technology, Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland 20850.
Na KeNew England Biolabs, Ipswich, Massachusetts 01938.
Colleen McClungNew England Biolabs, Ipswich, Massachusetts 01938.
Mehmet BerkmenNew England Biolabs, Ipswich, Massachusetts 01938.
Christina BergonzoNational Institute of Standards and Technology, Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland 20850.
Robert G BrinsonNational Institute of Standards and Technology, Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland 20850.
Zvi KelmanBiomolecular Labeling Laboratory, National Institute of Standards and Technology and Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland 20850; National Institute of Standards and Technology, Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland 20850. Electronic address: zkelman@umd.edu.
National Institute of Standards and Technology · USNew England Biolabs (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Monoclonal antibodies (mAbs) represent an important platform for the development of biotherapeutic products. Most mAbs are produced in mammalian cells, but several mAbs are made in

Indexed as

AdalimumabEscherichia coliImmunoglobulin Heavy ChainsPeptide Chain Initiation, TranslationalRecombinant ProteinsAdalimumabImmunoglobulin Heavy ChainsRecombinant Proteinscodon optimizationEscherichia coli (E. coli)GTG codonmAbmonoclonal antibodyNISTmAbprotein expressionrecombinant protein expressionShine-Dalgarno sequencetranslation initiationtranslation regulation

Identifiers

PMID31604819
PMCPMC6885640
OpenAlexW2980175902

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.