Trial reporteNeuro
Closed-Loop Acoustic Stimulation Enhances Sleep Oscillations But Not Memory Performance.
Trial report in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Memory retention following acoustic stimulation in slow-wave sleep: a meta-analytic review of replicability and measurement quality.Frontiers in sleep · 2023Pooled it
- A Systematic Review of Closed-Loop Feedback Techniques in Sleep Studies-Related Issues and Future Directions.Sensors (Basel, Switzerland) · 2020Pooled it
- The effectiveness of sound-based interventions on promoting sleep quality in hospitalized patients: A systematic review.iScience · 2026Article
- One night of closed-loop auditory stimulation during sleep enhances memory consolidation in patients with Alzheimer's Disease.medRxiv : the preprint server for health sciences · 2026Article
- Random auditory stimulation during sleep disturbs traveling slow waves and declarative memory.iScience · 2026Article
- The Effect of Closed-Loop Auditory Stimulation on Memory Consolidation and Sleep Physiology in an Ecological Setting.Journal of sleep research · 2026Article
- Sharp wave-ripple clusters enhance hippocampal-neocortical engagement for memory consolidation.bioRxiv : the preprint server for biology · 2026Article
- Auditory-evoked changes in slow oscillations and spindles correlate with memory consolidation in children with epilepsy and controls.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026Article
- Modulating sleep: slow oscillation and spindle stimulation effects on physiology and memory.NPJ science of learning · 2026Article
- Protocol for modulating anesthesia delta oscillations using closed loop auditory stimulation.Frontiers in human neuroscience · 2026Article
- Emerging neurotechnological approaches to management of sleep disturbances in Parkinson's disease.Clinical parkinsonism & related disorders · 2026Review
- Closed-loop acoustic stimulation modified by cathodal tDCS is beneficial for retention.bioRxiv : the preprint server for biology · 2025Article
- Stimulating the Stimulated Cortex-Frontocortical Anodal Electric Stimulation Combined With Closed-Loop Acoustic Stimulation During Sleep Impairs Memory in Subjects With High Cognitive Ability.The European journal of neuroscience · 2025Article
- Interictal network dysfunction and cognitive impairment in epilepsy.Nature reviews. Neuroscience · 2025Review
- Unraveling the neurophysiological correlates of phase-specific enhancement of motor memory consolidation via slow-wave closed-loop targeted memory reactivation.Nature communications · 2025Article
- Acoustic stimulation and other emerging approaches to enhance sleep: design notes for the next generation of closed-loop neurostimulation technology.Frontiers in neuroscience · 2025Review
- Closed-Loop Auditory Stimulation (CLAS) During Sleep Augments Language and Discovery Learning.Brain sciences · 2024Article
- Acoustically evoked K-complexes together with sleep spindles boost verbal declarative memory consolidation in healthy adults.Scientific reports · 2024Article
- A closed-loop auditory stimulation approach selectively modulates alpha oscillations and sleep onset dynamics in humans.PLoS biology · 2024Article
- Single closed-loop acoustic stimulation targeting memory consolidation suppressed hippocampal ripple and thalamo-cortical spindle activity in mice.The European journal of neuroscience · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Slow oscillations and spindle activity during non-rapid eye movement sleep have been implicated in memory consolidation. Closed-loop acoustic stimulation has previously been shown to enhance slow oscillations and spindle activity during sleep and improve verbal associative memory. We assessed the effect of closed-loop acoustic stimulation during a daytime nap on a virtual reality spatial navigation task in 12 healthy human subjects in a randomized within-subject crossover design. We show robust enhancement of slow oscillation and spindle activity during sleep. However, no effects on behavioral performance were observed when comparing real versus sham stimulation. To explore whether memory enhancement effects were task specific and dependent on nocturnal sleep, in a second experiment with 19 healthy subjects, we aimed to replicate a previous study that used closed-loop acoustic stimulation to enhance memory for word pairs. The methods used were as close as possible to those used in the original study, except that we used a double-blind protocol, in which both subject and experimenter were unaware of the test condition. Again, we successfully enhanced slow oscillation and spindle power, but again did not strengthen associative memory performance with stimulation. We conclude that enhancement of sleep oscillations may be insufficient to enhance memory performance in spatial navigation or verbal association tasks, and provide possible explanations for lack of behavioral replication.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.