ArticleNeurology2019
Regionally decreased gyrification in middle-aged adults with autism spectrum disorders.
Article in Neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Cognitive and Cerebral Aging Research in Autism: A Systematic Review on an Emerging Topic.Autism research : official journal of the International Society for Autism Research · 2025Pooled it
- Cognitive and brain morphological deviations in middle-to-old aged autistic adults: A systematic review and meta-analysis.Neuroscience and biobehavioral reviews · 2024Pooled it
- Cortical thickness abnormalities in autism spectrum disorder.European child & adolescent psychiatry · 2024Pooled it
- Cortical Gyrification Morphology in Individuals with ASD and ADHD across the Lifespan: A Systematic Review and Meta-Analysis.Cerebral cortex (New York, N.Y. : 1991) · 2021Pooled it
- Atypical Visually Guided Precision Grip Control in Middle-Aged and Older Autistic Adults.Autism research : official journal of the International Society for Autism Research · 2026Article
- Interoceptive Dysfunction in Psychiatric Disorders and Non-invasive Neuromodulation for Improving Interoception.Neuroscience bulletin · 2025Review
- Transcallosal white matter and cortical gray matter variations in autistic adults aged 30-73 years.Molecular autism · 2025Article
- An MRI Study of Morphology, Asymmetry, and Sex Differences of Inferior Precentral Sulcus.Brain topography · 2024Article
- Associations between atypical intracortical myelin content and neuropsychological functions in middle to older aged adults with ASD.Brain and behavior · 2024Article
- Cerebral Cortical Surface Structure and Neural Activation Pattern Among Adolescent Football Players.JAMA network open · 2024Article
- Structural brain morphology in young adult women who have been choked/strangled during sex: A whole-brain surface morphometry study.Brain and behavior · 2023Article
- A resting-state functional magnetic resonance imaging study of altered functional brain activity in cardiac arrest survivors with good neurological outcome.Frontiers in neurology · 2023Article
- Structural neuroimaging phenotypes and associated molecular and genomic underpinnings in autism: a review.Frontiers in neuroscience · 2023Review
- Cortical Gyrification Morphology in ASD and ADHD: Implication for Further Similarities or Disorder-Specific Features?Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- The role of head circumference and cerebral volumes to phenotype male adults with autism spectrum disorder.Brain and behavior · 2022Article
- Hypogyrification in Generalized Anxiety Disorder and Associated with Insomnia Symptoms.Nature and science of sleep · 2022Article
- Cortical Morphology in Autism: Findings from a Cortical Shape-Adaptive Approach to Local Gyrification Indexing.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Left Cerebral Cortex Complexity in Patients with Major Depression Disorder: A Small-Sample Pilot Study.Psychiatry and clinical psychopharmacology · 2021Article
- Structural, Functional, and Molecular Imaging of Autism Spectrum Disorder.Neuroscience bulletin · 2021Review
- Cortical gyrification morphology in PTSD: A neurobiological risk factor for severity?Neurobiology of stress · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo examine changing features of cortical morphology in middle-aged adults with autism spectrum disorders (ASDs) vs typical comparison (TC) participants, hypothesizing regionally decreased local gyrification index (lGI), given our previous findings of accelerated lGI decline during adolescence.
methodsAfter quality assurance, T1-weighted MRI sequences from 20 participants with ASD and 21 TC participants (40-61 years) matched on age were analyzed. lGI, cortical thickness (CT), and surface area (SA) were measured with FreeSurfer version 5.3. Statistical analyses used a general linear model including age, nonverbal IQ, and total brain volume as covariates. Clusters of significant group effects were used as regions of interest for behavioral analyses.
resultsClusters of decreased lGI were observed bilaterally in the ASD group with large effect sizes in insular and anterior cingulate (ACC), left postcentral, and middle frontal and right orbitofrontal and supramarginal regions. lGI was also shown to decline with age across groups in bilateral precentral and right supramarginal clusters. No significant group, age, or group-by-age interaction effects were observed for CT or SA in this age group. lGI showed a significant correlation with Social Responsiveness Scale total scores in a right caudal ACC cluster in the TC group only, while several correlations were found in the ASD group between executive function scores and clusters in the bilateral insula and right orbitofrontal cortex.
conclusionThe pattern of regionally decreased lGI observed here in middle-aged adults with ASDs is consistent with an abnormal trajectory of cortical folding changes across different stages of life in ASDs, as shown in previous studies.
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