Evidence map›Paper›PMID 31604714›Full record

ArticleBMJ case reports2019

Off-label application of intravenous immunoglobulin (IVIG) for treatment of Cogan's syndrome during pregnancy.

Felix Scherg, Friedrich Haag, Thorsten Krieger

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in BMJ case reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Changes of serum immunoglobulin level in healthy pregnant women and establishment of its reference interval.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2021
    Article
  2. Pregnancy Outcomes in Systemic Vasculitides.Current rheumatology reports · 2020
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Felix SchergInstitute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Friedrich HaagInstitute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Thorsten KriegerInstitute of Clinical Chemistry, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Universität Hamburg · DEUniversity Medical Center Hamburg-Eppendorf · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report the case of a woman with Cogan's syndrome concomitant with the wish to have children. After three major flares of the disease that led to unilateral deafness, immunosuppressive therapy with prednisolone and azathioprine was started. Because of the severe side effects, an off-label therapy with intravenous immunoglobulin (IVIG) was initiated, under which our patient has since given birth to three healthy children. To our knowledge this is the first report to describe Cogan's syndrome with multiple successful pregnancies under IVIG treatment.

Indexed as

Off-Label UseAdultCogan SyndromeFemaleHearing LossHumansImmunoglobulins, IntravenousPregnancyPregnancy ComplicationsPregnancy OutcomeVertigoImmunoglobulins, Intravenousear, nose And throatimmunologypregnancy

Identifiers

PMID31604714
PMCPMC6803144
OpenAlexW2980156575

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.