ArticleDevelopment (Cambridge, England)2019
Molecular and mechanical signals determine morphogenesis of the cerebral hemispheres in the chicken embryo.
Article in Development (Cambridge, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Multiscale Modeling of Embryonic Morphogenesis from Fertilization to Organogenesis.NPJ systems biology and applications · 2026Review
- Embryonic cerebrospinal fluid pressure in fetal mice in utero: External factors pressurize the intraventricular space.Developmental dynamics : an official publication of the American Association of Anatomists · 2026Article
- Morphometric analysis reveals that the chick cranial neural tube expands as an active shell.bioRxiv : the preprint server for biology · 2026Article
- BEADS: An Interactive Semi-Automated Workflow for 3D Fibrin Angiogenesis Assays Enabling Co-Culture and Directionality Analysis.bioRxiv : the preprint server for biology · 2025Article
- Modular Parallel Plate Flow Chamber with Tunable Substrate Mechanics and Defined Shear Stress.bioRxiv : the preprint server for biology · 2025Article
- Confocal-Compatible Workflow for Sectioning, Staining, and Imaging Serial Vibratome Sections for 3D Anatomical Reconstruction of the Lymph Node.bioRxiv : the preprint server for biology · 2025Article
- Differential tissue deformability underlies fluid pressure-driven shape divergence of the avian embryonic brain and spinal cord.Developmental cell · 2025Article
- Mechanical stress connects cortical folding to fiber organization in the developing brain.Trends in neurosciences · 2025Review
- Measuring intraventricular pressure in developing mouse embryos: Uncovering a repetitive mechanical cue for brain development.Development, growth & differentiation · 2025Article
- Anatomical and Embryological Development of the Chick Cerebrum in Different Embryonic Periods.Veterinary medicine and science · 2025Article
- Zonal patterning of extracellular matrix and stromal cell populations along a perfusable cellular microchannel.Lab on a chip · 2024Article
- Zonal Patterning of Extracellular Matrix and Stromal Cell Populations Along a Perfusable Cellular Microchannel.bioRxiv : the preprint server for biology · 2024Article
- Article
- A chemo-mechanical model of endoderm movements driving elongation of the amniote hindgut.Development (Cambridge, England) · 2023Article
- Cellular mechanotransduction in health and diseases: from molecular mechanism to therapeutic targets.Signal transduction and targeted therapy · 2023Review
- A chemo-mechanical model of endoderm movements driving elongation of the amniote hindgut.bioRxiv : the preprint server for biology · 2023Article
- Biomechanical models and mechanisms of cellular morphogenesis and cerebral cortical expansion and folding.Seminars in cell & developmental biology · 2023Review
- Developmentally interdependent stretcher-compressor relationship between the embryonic brain and the surrounding scalp in the preosteogenic head.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Article
- Neuromechanobiology: An Expanding Field Driven by the Force of Greater Focus.Advanced healthcare materials · 2021Review
- Mechanics of Development.Developmental cell · 2021Review
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Authors and funding
5 authors.
Funding
Abstract
During embryonic development, the telecephalon undergoes extensive growth and cleaves into right and left cerebral hemispheres. Although molecular signals have been implicated in this process and linked to congenital abnormalities, few studies have examined the role of mechanical forces. In this study, we quantified morphology, cell proliferation and tissue growth in the forebrain of chicken embryos during Hamburger-Hamilton stages 17-21. By altering embryonic cerebrospinal fluid pressure during development, we found that neuroepithelial growth depends on not only chemical morphogen gradients but also mechanical feedback. Using these data, as well as published information on morphogen activity, we developed a chemomechanical growth law to mathematically describe growth of the neuroepithelium. Finally, we constructed a three-dimensional computational model based on these laws, with all parameters based on experimental data. The resulting model predicts forebrain shapes consistent with observations in normal embryos, as well as observations under chemical or mechanical perturbation. These results suggest that molecular and mechanical signals play important roles in early forebrain morphogenesis and may contribute to the development of congenital malformations.
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