ArticlePediatric neurology2020
Brain Magnetic Resonance Imaging Findings Associated With Cognitive Impairment in Children and Adolescents With Human Immunodeficiency Virus in Zambia.
Article in Pediatric neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05678660 (Study of Neurological Aging Among People Living With HIV), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study of Neurological Aging Among People Living With HIV (SNAP)
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Associations between Neuroimaging Measures and Cognitive Performance in Children, Adolescents, and Youth Living With HIV-a Systematic Review.Current HIV/AIDS reports · 2025Pooled it
- Executive Function and Adherence in Children and Adolescents Living With HIV: Evidence From the HIV-Associated Neurocognitive Disorders in Zambia (HANDZ) Study.Journal of child neurology · 2026Article
- Nutritional Status and Cognitive Function in Children With or Exposed to HIV: Evidence From the HIV-Associated Neurocognitive Disorders in Zambia Study.Journal of acquired immune deficiency syndromes (1999) · 2026Article
- Brain Imaging in New-Onset Seizure of Children Living With Human Immunodeficiency Virus in Zambia.Pediatric neurology · 2024Article
- Adherence, Adverse Events and Viral Control among Children and Adolescents with HIV in Zambia Switched to an Integrase Inhibitor Regimen.medRxiv : the preprint server for health sciences · 2024Article
- Central Nervous System Complications of HIV in Children.Current HIV/AIDS reports · 2024Review
- Validation of the National Institute of Health Toolbox Cognition Battery (NIHTB-CB) in Children and Adolescents with and without HIV Infection in Lusaka, Zambia.AIDS and behavior · 2022Article
- Central Nervous System Impact of Perinatally Acquired HIV in Adolescents and Adults: an Update.Current HIV/AIDS reports · 2022Review
- Neighborhood-Based Socioeconomic Determinants of Cognitive Impairment in Zambian Children With HIV: A Quantitative Geographic Information Systems Approach.Journal of the Pediatric Infectious Diseases Society · 2021Article
- Reduced neuronal population in the dorsolateral prefrontal cortex in infant macaques infected with simian immunodeficiency virus (SIV).Journal of neurovirology · 2021Article
- Article
- Cerebrovascular Disease in Children Perinatally Infected With Human Immunodeficiency Virus in Zambia.Pediatric neurology · 2020Article
- Cerebral toxoplasmosis in HIV-infected patients over 2015-2018 (a case study of Russia).Epidemiology and infection · 2020Article
- Brain morphometric differences in youth with and without perinatally-acquired HIV: A cross-sectional study.NeuroImage. Clinical · 2020Article
- Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundCognitive impairment is common in children and adolescents with human immunodeficiency virus (HIV). Brain magnetic resonance imaging (MRI) is a potentially useful tool to investigate the pathophysiology of HIV-associated cognitive impairment and may serve as a biomarker in future clinical trials. There are few published data on brain imaging in children with HIV in sub-Saharan Africa.
methodsThirty-four perinatally infected subjects with HIV and age-matched HIV-exposed uninfected controls between the ages nine and 17 years were recruited from the Pediatric Center of Excellence in Lusaka, Zambia, as part of the HIV-associated Neurocognitive Disorders in Zambia study. Brain MRI sequences were acquired, and clinical and volumetric assessments were performed. Subjects underwent a comprehensive neuropsychologic battery, and cognitive impairment status was classified using a global deficit score approach. Regression models were used to evaluate relationships between MRI findings and cognitive function.
resultsWe identified cerebrovascular disease in seven of 34 subjects with HIV compared with zero of 17 controls (21% vs 0%, P = 0.04). We also identified decreased total brain volumes (1036 vs 1162 cm
conclusionsThese findings support the hypothesis that brain volumes may be useful biomarkers for cognitive outcomes in children with HIV. Further studies are necessary to investigate mechanisms of cerebrovascular disease and volume loss in children with HIV.
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Registered trials
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