Evidence map›Paper›PMID 31604480›Full record

ArticleTrials2019

Frequency of Screening and SBT Technique Trial - North American Weaning Collaboration (FAST-NAWC): a protocol for a multicenter, factorial randomized trial.

K E A Burns, Leena Rizvi, Deborah J Cook, Andrew J E Seely, Bram Rochwerg, Francois Lamontagne, John W Devlin, Peter Dodek, Michael Mayette, Maged Tanios and 6 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02399267 (The Frequency of Screening and SBT Technique Trial), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02399267 naunknown statusnot on this map

The Frequency of Screening and SBT Technique Trial

TypeinterventionalSponsorUnity Health TorontoRan2016 to 2021Enrolled100ConditionsCritically IllArmsOnce daily screening, Twice daily screening, PS SBTs, T-piece SBTs
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Guideline
  2. Trial
  3. Article
  4. Article
  5. Biosignal-Based Digital Biomarkers for Prediction of Ventilator Weaning Success.International journal of environmental research and public health · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 3 countries.

K E A BurnsInterdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada. burnsk@smh.ca.ORCID http://orcid.org/0000-0002-9967-5424
Leena RizviDepartment of Medicine, Division of Critical Care Medicine, St Michael's Hospital, 30 Bond Street, Office 4-045 Donnelly Wing, Toronto, ON, M5B 1W8, Canada.
Deborah J CookDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
Andrew J E SeelyOttawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.
Bram RochwergDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
Francois LamontagneCentre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada.
John W DevlinSchool of Pharmacy, Northeastern University, Boston, MA, USA.
Peter DodekCentre for Health Evaluation and Outcome Sciences, Vancouver, BC, Canada.
Michael MayetteCentre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada.
Maged TaniosCritical Care Medicine, Longbeach Memorial, Longbeach, CA, USA.
Audrey GouskosPatient and Family Advisory Committee Member, FAST - NAWC Trial, Toronto, Canada.
Phyllis KayPatient and Family Advisory Committee Member, FAST - NAWC Trial, Toronto, Canada.
Susan MitchellPatient and Family Advisory Committee Member, FAST - NAWC Trial, Toronto, Canada.
Kenneth C KiedrowskiPatient and Family Advisory Committee Member, FAST - NAWC Trial, Toronto, Canada.
Nicholas S HillDivision of Pulmonary, Critical Care and Sleep Medicine, Tufts Medical Center, Boston, MA, USA.
Canadian Critical Care Trials Group
Advisory Board Company (United States) · USCentre Hospitalier Universitaire de Sherbrooke · CAImpact · CASt. Michael's Hospital · CATufts Medical Center · USUniversity of British Columbia · CAUniversity of Ottawa · CA

Funding

CIHR NA
6 · The paper itself

Abstract

rationaleIn critically ill patients receiving invasive mechanical ventilation (MV), research supports the use of daily screening to identify patients who are ready to undergo a spontaneous breathing trial (SBT) followed by conduct of an SBT. However, once daily (OD) screening is poorly aligned with the continuous care provided in most intensive care units (ICUs) and the best SBT technique for clinicians to use remains controversial.

objectivesTo identify the optimal screening frequency and SBT technique to wean critically ill adults in the ICU.

methodsWe aim to conduct a multicenter, factorial design randomized controlled trial with concealed allocation, comparing the effect of both screening frequency (once versus at least twice daily [ALTD]) and SBT technique (Pressure Support [PS] + Positive End-Expiratory Pressure [PEEP] vs T-piece) on the time to successful extubation (primary outcome) in 760 critically ill adults who are invasively ventilated for at least 24 h in 20 North American ICUs. In the OD arm, respiratory therapists (RTs) will screen study patients between 06:00 and 08:00 h. In the ALTD arm, patients will be screened at least twice daily between 06:00 and 08:00 h and between 13:00 and 15:00 h with additional screens permitted at the clinician's discretion. When the SBT screen is passed, an SBT will be conducted using the assigned technique (PS + PEEP or T-piece). We will follow patients until successful extubation, death, ICU discharge, or until day 60 after randomization. We will contact patients or their surrogates six months after randomization to assess health-related quality of life and functional status. RELEVANCE: The around-the-clock availability of RTs in North American ICUs presents an important opportunity to identify the optimal SBT screening frequency and SBT technique to minimize patients' exposure to invasive ventilation and ventilator-related complications.

trial registrationClinical Trials.gov, NCT02399267 . Registered on Nov 21, 2016 first registered.

Indexed as

RespirationRespiration, ArtificialRespiratory Function TestsVentilator WeaningAirway ExtubationCritical IllnessHumansLungMulticenter Studies as TopicNorth AmericaPredictive Value of TestsRandomized Controlled Trials as TopicRecovery of FunctionTime FactorsTreatment OutcomeRandomized controlled trialScreeningSpontaneous breathing trialSuccessful extubationWeaning

Identifiers

PMID31604480
PMCPMC6787986
OpenAlexW2979587958

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.