ArticleScience (New York, N.Y.)2019
Chromosome errors in human eggs shape natural fertility over reproductive life span.
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Article in Science (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 257 papers, 1 of them a synthesis that pooled it.
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257citing papers in PubMed, 1 pooled it
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Who cites it
257 citing papers in PubMed, 1 synthesis or guideline pooled it, 453 citations in OpenAlex.
- Pharmacogenomic studies of fertility outcomes in pediatric cancer survivors - A systematic review.Clinical and translational science · 2024Pooled it
- Declining ribosome function limits oocyte longevity.bioRxiv : the preprint server for biology · 2026Article
- The Meiotic Spindle, Mechanisms of Chromosome Segregation and Aneuploidy in Aging Human Oocytes: An Update Review.Medicina (Kaunas, Lithuania) · 2026Review
- Maternal age as a driver of genome instability: mechanisms linking aneuploidy, mutagenesis and mitochondrial dysfunction.Archives of toxicology · 2026Review
- Mapping ovarian cellular and molecular landscape across the lifespan of women: a scoping review.Human reproduction update · 2026Article
- Spaceborne and spaceborn: Physiological aspects of pregnancy and birth during interplanetary flight.Experimental physiology · 2026Review
- A human CEP120 gene variant impairs meiotic spindle building causing aneuploidy†.Biology of reproduction · 2026Article
- Ovarian Extracellular Matrix Mechanics Regulate Oocyte-Follicle Interactions During Female Reproductive Aging.Aging cell · 2026Article
- High-resolution chromatin mapping reveals that CTCF anchors meiotic loops to the chromosome axis.Nature communications · 2026Article
- A variant in human leucine-rich repeat and coiled-coil domain-containing 1 (LRRCC1) elevates meiotic aneuploidy in oocytes.Research square · 2026Article
- From Cytoskeletal Remodeling to Oocyte Quality: The Emerging Role of Mechanics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Cumulus Expansion and Oocyte Quality Across the Pubertal Transition in Mice: Implications for Modeling Fertility Preservation in Adolescents.Research square · 2026Article
- BDNF secreted by mesenchymal stem cells ameliorates the accelerated meiotic progression in aged mouse oocytes by activating the PI3K/AKT pathway.Stem cell research & therapy · 2026Article
- Molecular assessment of recombination processing across genetically diverse mouse strains reveals sexually dimorphic determinants of crossover distribution beyond chromosome length.Molecular biology and evolution · 2026Article
- A cohesion optimum underlies chromosome segregation fidelity in oocytes.bioRxiv : the preprint server for biology · 2026Article
- Probing Proteoform Heterogeneity From Single Human Oocytes.Molecular & cellular proteomics : MCP · 2026Article
- The tiny germline chromosomes of Paramecium aurelia have an exceptionally high recombination rate and are capped by a new class of Helitrons.BMC biology · 2026Article
- Oocyte aging in focus: Environmental and endogenous stressors driving reproductive potential decline.GeroScience · 2026Review
- Beyond euploidy: the synergistic value of blastocyst morphology in predicting ongoing implantation in advanced maternal age women.Reproduction & fertility · 2026Article
- Article
197 more citing papers are in PubMed but not listed here.
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Authors and funding
30 authors at 15 institutions in 6 countries.
Jennifer R Gruhn *DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.ORCID 0000-0002-4093-142X
Agata P Zielinska *Max Planck Institute for Biophysical Chemistry, Department of Meiosis, Göttingen, Germany.ORCID 0000-0003-4208-0072
Vallari Shukla *DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.ORCID 0000-0003-3329-5418
Robert Blanshard *Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK.ORCID 0000-0002-8280-3733
Antonio CapalboIgenomix, Marostica, Italy.
Danilo CimadomoG.en.e.r.a., Centers for Reproductive Medicine, Clinica Valle Giulia, via de notaris 2b, 00197 Rome, Italy.
Dmitry NikiforovLaboratory of Reproductive Biology, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.ORCID 0000-0002-8523-3035
Andrew Chi-Ho ChanDNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Louise J NewnhamGenome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK.
Ivan VogelDNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Catello ScaricaDAHFMO, Unit of Histology and Medical Embryology, Sapienza, University of Rome, Italy.
Marta KrapchevINVICTA Fertility and Reproductive Center, Gdańsk, Poland.ORCID 0000-0002-4419-1481
Deborah TaylorWarwick Medical School, University of Warwick and Centre for Reproductive Medicine, University Hospital Coventry, UK.ORCID 0000-0001-7334-5411
Stine Gry KristensenLaboratory of Reproductive Biology, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.ORCID 0000-0003-1194-8393
Junping ChengLaboratory of Reproductive Biology, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Erik ErnstDepartment of Obstetrics and Gynaecology, University Hospital of Aarhus, Skejby Sygehus, Aarhus, Denmark.
Anne-Mette Bay BjørnDepartment of Obstetrics and Gynaecology, University Hospital of Aarhus, Skejby Sygehus, Aarhus, Denmark.
Lotte Berdiin ColmornThe Fertility Clinic, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Rigshospitalet, Denmark.
Martyn BlayneyBourn Hall Clinic, Cambridge, UK.
Kay ElderBourn Hall Clinic, Cambridge, UK.ORCID 0000-0003-3510-8268
Joanna LissINVICTA Fertility and Reproductive Center, Gdańsk, Poland.ORCID 0000-0002-9199-5212
Geraldine HartshorneWarwick Medical School, University of Warwick and Centre for Reproductive Medicine, University Hospital Coventry, UK.ORCID 0000-0003-2070-8471
Marie Louise GrøndahlDepartment of Obstetrics and Gynaecology, Department of Reproductive Medicine, Copenhagen University Hospital Herlev, Denmark.
Laura RienziG.en.e.r.a., Centers for Reproductive Medicine, Clinica Valle Giulia, via de notaris 2b, 00197 Rome, Italy.
Filippo UbaldiG.en.e.r.a., Centers for Reproductive Medicine, Clinica Valle Giulia, via de notaris 2b, 00197 Rome, Italy.
Rajiv McCoyDepartment of Biology, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0003-0615-146X
Krzysztof LukaszukINVICTA Fertility and Reproductive Center, Gdańsk, Poland.ORCID 0000-0001-5996-6991
Claus Yding AndersenLaboratory of Reproductive Biology, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Melina SchuhMax Planck Institute for Biophysical Chemistry, Department of Meiosis, Göttingen, Germany.ORCID 0000-0003-0025-8952
Eva R HoffmannDNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark. eva@sund.ku.dk.ORCID 0000-0002-2588-0652
University of Copenhagen · DKCopenhagen University Hospital · DKClinica Valle Giulia · ITAarhus University Hospital · DKBourn Hall Clinic · GBMax Planck Institute for Biophysical Chemistry · DEUniversity Hospital Coventry · GBUniversity of Sussex · GBGdańsk Medical University · PLIgenomix · ITJohns Hopkins University · USMedical University of Warsaw · PLRigshospitalet · DKSapienza University of Rome · ITUniversity of Teramo · IT
Funding
Function and fitness consequences of human genetic variationR35GM133747 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Rajiv Champion McCoy · 2019 to 2026
$3.3MEuropean Research Council 337415European Research Council 724718Medical Research Council MR/M000664/1NIGMS NIH HHS R35 GM133747
Abstract
Chromosome errors, or aneuploidy, affect an exceptionally high number of human conceptions, causing pregnancy loss and congenital disorders. Here, we have followed chromosome segregation in human oocytes from females aged 9 to 43 years and report that aneuploidy follows a U-curve. Specific segregation error types show different age dependencies, providing a quantitative explanation for the U-curve. Whole-chromosome nondisjunction events are preferentially associated with increased aneuploidy in young girls, whereas centromeric and more extensive cohesion loss limit fertility as women age. Our findings suggest that chromosomal errors originating in oocytes determine the curve of natural fertility in humans.
Indexed as
AgingAneuploidyChromosome SegregationFertilityAdolescentAdultChildFemaleHumansMeiosisNondisjunction, GeneticOocytesYoung Adult
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