ArticleScience (New York, N.Y.)2019
Spatiotemporal immune zonation of the human kidney.
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Article in Science (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 263 papers.
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263citing papers in PubMed
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263 citing papers in PubMed.
- Single-cell RNA sequencing identifies a proinflammatory S100a8/a9Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- Engineered human induced pluripotent stem cell models reveal altered podocytogenesis in congenital heart disease-associated SMAD2 mutations.Nature biomedical engineering · 2026Article
- Mechanisms of regeneration and maladaptive repair in acute kidney injury.Nature reviews. Nephrology · 2026Review
- Urinary tract infections in children.Nature reviews. Urology · 2026Review
- Proteome-wide Mendelian randomization identifies APOM and TNXB as actionable mediators of steroid-sensitive nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2026Article
- Modelling ischaemic AKI in human kidney organoids reveals injury-associated epithelial states and macrophage-epithelial crosstalk.Genome medicine · 2026Article
- Plasma Proteomics in IgA Nephropathy: From Circulating Biomarkers to Molecular Endotypes.Cells · 2026Review
- Special Issue: Recent Research on Hypertension and Related Complications.International journal of molecular sciences · 2026Article
- Longitudinal multiomic and spatial transcriptomic profiling of lupus nephritis progression in a murine model.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Nephrotoxicity of Immune Checkpoint Inhibitors in Mice with a Human Immune System.bioRxiv : the preprint server for biology · 2026Article
- Cross-species comparison of amniote single-cell transcriptomes reveals evolutionary conservation and divergence in the chicken immune system.Nature communications · 2026Article
- Spatial atlas of human diabetic kidney uncovered podocyte-driven metabolic-inflammatory crosstalk via glycerolipid reprogramming and DUSP4/MMP3 axis.Fundamental research · 2026Article
- Article
- CX3CR1-T280M polymorphism and end-stage renal disease development in chronic kidney disease.Scientific reports · 2026Observational
- Predicting Macrophage Spatial Localization from Single-Cell Transcriptomes to Uncover Disease Mechanisms.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Developmental reprogramming underlies chemotherapy resistance in favorable-histology Wilms tumor.Cell reports · 2026Article
- A Subset of Pro-inflammatory CXCL10+ LILRB2+ Macrophages Derives From Recipient Monocytes and Drives Renal Allograft Rejection.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- CLEC18A interacts with sulfated glycosaminoglycans and controls clear cell renal cell carcinoma progression.The FEBS journal · 2026Article
- Mucosal-associated invariant T cells and the gut-kidney axis: a review.Clinical kidney journal · 2026Review
- From GWAS Signals to Causal Genes in Chronic Kidney Disease.Current issues in molecular biology · 2026Review
203 more citing papers are in PubMed but not listed here.
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Authors and funding
43 authors.
Benjamin J Stewart *Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK.ORCID 0000-0003-4522-0085
John R Ferdinand *Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK.ORCID 0000-0003-0936-0128
Matthew D YoungWellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.ORCID 0000-0003-0937-5290
Thomas J MitchellCambridge University Hospitals NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK.ORCID 0000-0003-0761-9503
Kevin W LoudonMolecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK.ORCID 0000-0001-9055-6894
Alexandra M RidingMolecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK.ORCID 0000-0002-6915-5671
Nathan RichozMolecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK.
Gordon L FrazerMolecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK.
Joy U L StaniforthMolecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK.ORCID 0000-0003-2817-0098
Felipe A Vieira BragaWellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.ORCID 0000-0003-0206-9258
Rachel A BottingInstitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.ORCID 0000-0001-9595-4605
Dorin-Mirel PopescuInstitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Roser Vento-TormoWellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.
Emily StephensonInstitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.ORCID 0000-0002-4244-4019
Alex CaganWellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.ORCID 0000-0002-7857-4771
Sarah J FarndonWellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.ORCID 0000-0001-6024-4267
Krzysztof PolanskiWellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.ORCID 0000-0002-2586-9576
Mirjana EfremovaWellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.
Kile GreenInstitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Martin Del Castillo Velasco-HerreraWellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.ORCID 0000-0001-5956-0211
Charlotte GuzzoWellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.ORCID 0000-0003-3742-5961
Grace CollordCambridge University Hospitals NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK.ORCID 0000-0003-1924-4411
Lira MamanovaWellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.ORCID 0000-0003-1463-8622
Tevita AhoCambridge University Hospitals NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK.ORCID 0000-0001-8456-9285
James N ArmitageCambridge University Hospitals NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK.
Antony C P RiddickCambridge University Hospitals NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK.
Imran MushtaqGreat Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.ORCID 0000-0002-7930-0342
Stephen FarrellCambridge University Hospitals NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK.
Dyanne RamplingGreat Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.
James NicholsonCambridge University Hospitals NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK.
Andrew FilbyInstitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Johanna BurgeCambridge University Hospitals NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK.
Steven LisgoHuman Developmental Biology Resource, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne NE1 3BZ, UK.ORCID 0000-0001-5186-3971
Susan LindsayHuman Developmental Biology Resource, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne NE1 3BZ, UK.ORCID 0000-0003-2980-4582
Marc BajenoffCentre d'Immunologie de Marseille-Luminy, 13009 Marseille, France.
Anne Y WarrenCambridge University Hospitals NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK.
Grant D StewartCambridge University Hospitals NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK.ORCID 0000-0003-3188-9140
Neil SebireGreat Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK.
Nicholas ColemanCambridge University Hospitals NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK.
Muzlifah HaniffaWellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK.ORCID 0000-0002-3927-2084
Sarah A TeichmannWellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK. mrc38@cam.ac.uk sb31@sanger.ac.uk st9@sanger.ac.uk m.a.haniffa@newcastle.ac.uk.ORCID 0000-0002-6294-6366
Sam BehjatiCambridge University Hospitals NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK.ORCID 0000-0002-6600-7665
Menna R ClatworthyMolecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK.ORCID 0000-0002-3340-9828
Funding
Cancer Research UK 27176Department of Health RP-2017-08-ST2-002Medical Research Council MR/N024907/1Medical Research Council MR/S035842/1
Abstract
Tissue-resident immune cells are important for organ homeostasis and defense. The epithelium may contribute to these functions directly or by cross-talk with immune cells. We used single-cell RNA sequencing to resolve the spatiotemporal immune topology of the human kidney. We reveal anatomically defined expression patterns of immune genes within the epithelial compartment, with antimicrobial peptide transcripts evident in pelvic epithelium in the mature, but not fetal, kidney. A network of tissue-resident myeloid and lymphoid immune cells was evident in both fetal and mature kidney, with postnatal acquisition of transcriptional programs that promote infection-defense capabilities. Epithelial-immune cross-talk orchestrated localization of antibacterial macrophages and neutrophils to the regions of the kidney most susceptible to infection. Overall, our study provides a global overview of how the immune landscape of the human kidney is zonated to counter the dominant immunological challenge.
Indexed as
AdultAnimalsEpithelial CellsFemaleFetusGene Expression Regulation, DevelopmentalHumansKidneyLymphocytesMacrophagesMice, Inbred C57BLMice, TransgenicMyeloid CellsNeutrophilsRNA-SeqSingle-Cell Analysis
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.