Evidence map›Paper›PMID 31604170›Full record

ArticleAtherosclerosis2019

Genital Chlamydia infection in hyperlipidemic mouse models exacerbates atherosclerosis.

Uma M Nagarajan, James D Sikes, Ramona L Burris, Rajneesh Jha, Branimir Popovic, Pamelia Fraungruber, Leah Hennings, Catherine L Haggerty, Shanmugam Nagarajan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Atherosclerosis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Current Evidence of Maternal Infection With Chlamydia trachomatis and Preeclampsia Risk.American journal of reproductive immunology (New York, N.Y. : 1989) · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Uma M NagarajanDepartment of Pediatrics and Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children's Hospital Research Institute, Little Rock, AR, USA.
James D SikesDepartment of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children's Hospital Research Institute, Little Rock, AR, USA.
Ramona L BurrisDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences, Arkansas Children's Hospital Research Institute, Little Rock, AR, USA.
Rajneesh JhaDepartment of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children's Hospital Research Institute, Little Rock, AR, USA.
Branimir PopovicDepartment of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.
Pamelia FraungruberDepartment of Pathology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Leah HenningsDepartment of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Catherine L HaggertyDepartment of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA.
Shanmugam NagarajanDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences, Arkansas Children's Hospital Research Institute, Little Rock, AR, USA; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA; Department of Pathology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address: shannag@med.unc.edu.
University of Arkansas for Medical Sciences · USUniversity of North Carolina at Chapel Hill · USUniversity of Pittsburgh · US

Funding

Molecular Mechanisms of Type I IFN Induction during Chlamydia InfectionR01AI067678 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NAGARAJAN, UMA M · 2007 to 2018
$3.5M
Role of Fc gamma receptors in atherosclerosisR01HL086674 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NAGARAJAN, SHANMUGAM · 2008 to 2012
$1.8M
The Impact of Fc gamma Receptor Signaling on Lupus-Induced AtherosclerosisR01HL130126 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NAGARAJAN, SHANMUGAM · 2016 to 2019
$1.5M
IRF3 is a novel mediator of cell death during genital Chlamydia infection.R21AI124010 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NAGARAJAN, UMA M · 2016 to 2017
$418k
NHLBI NIH HHS R01 HL086674NHLBI NIH HHS R01 HL130126NIAID NIH HHS R01 AI067678NIAID NIH HHS R21 AI124010
6 · The paper itself

Abstract

BACKGROUND AND

aimsAtherosclerosis is a chronic inflammatory disease, and recent studies have shown that infection at remote sites can contribute to the progression of atherosclerosis in hyperlipidemic mouse models. In this report, we tested the hypothesis that genital Chlamydia infection could accelerate the onset and progression of atherosclerosis.

methodsApolipoprotein E (Apoe

resultsCompared to the uninfected groups, infected Apoe

conclusionsOverall, these studies demonstrate that genital Chlamydia infection exacerbates atherosclerotic lesions in hyperlipidemic mouse and suggest a novel role for Apoe in full recovery of uterine anatomy after chlamydial infection.

Indexed as

AnimalsAortic DiseasesAtherosclerosisCells, CulturedChlamydia InfectionsChlamydia muridarumCytokinesDisease Models, AnimalDisease ProgressionFemaleHyperlipidemiasInflammation MediatorsMacrophagesMice, Knockout, ApoEPlaque, AtheroscleroticReceptors, LDLCytokinesInflammation MediatorsReceptors, LDLAtherosclerosisChlamydiaInflammationUterine pathology

Identifiers

PMID31604170
PMCPMC8552421
OpenAlexW2975187129

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.