ArticleBrain, behavior, and immunity2020
The longitudinal relationship between changes in wellbeing and inflammatory markers: Are associations independent of depression?
Article in Brain, behavior, and immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed.
- Feasibility, Acceptability, and Preliminary Efficacy of a Positive Psychology Intervention in Patients With Coronary Heart Disease: A Randomized Controlled Trial.Journal of the Academy of Consultation-Liaison PsychiatryTrial
- Association between psychological wellbeing and the COVID-19-related outcomes in Europeans aged ≥ 50 years old: The SHARE study.Human vaccines & immunotherapeutics · 2026Article
- Associations between plasma proteins and psychological wellbeing: evidence from over 20 years of the English Longitudinal Study of Ageing.Molecular psychiatry · 2026Article
- Perceived stress precedes declines in Well-being: A prospective study of stress, well-being, hair cortisol, and low-grade inflammation in hospital employees.Brain, behavior, & immunity - health · 2026Article
- Loneliness and sarcopenia in aged care: the mediating role of fatigability.Innovation in aging · 2026Article
- Associations between plasma proteins and psychological wellbeing: evidence from over 20 years of the English Longitudinal Study of Ageing.medRxiv : the preprint server for health sciences · 2025Article
- Association between subjective well-being and the risk of cardiovascular diseases among older adults: evidence from the Chinese longitudinal healthy longevity survey.BMC geriatrics · 2025Article
- The Role of Metabolic Disorders and Laboratory Abnormalities in Wound Healing and Recovery in Geriatric and Non-Geriatric Orthopedic Patients in Poland-Prospective Research.Journal of clinical medicine · 2025Article
- Preliminary Evidence of Higher Production of LPS-induced Proinflammatory Cytokines in Retired Versus Employed Dementia Caregivers.Biopsychosocial science and medicine · 2025Article
- How happy is healthy enough? Uncovering the happiness threshold for global non-communicable disease prevention.Frontiers in medicine · 2025Article
- A healthful plant-based diet is associated with higher health-related quality of life among older adults independent of circulating CRP: a cross-sectional analysis from the Lifelines Cohort Study.Journal of nutritional science · 2025Article
- Well-Being and Cardiovascular Health: Insights From the UK Biobank Study.Journal of the American Heart Association · 2024Article
- Positive psychological well-being and cardiovascular health.Frontiers in psychiatry · 2024Review
- Reduced Epigenetic Age in Older Adults With High Sense of Purpose in Life.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Effectiveness and Feasibility of a Self-guided Mobile App Targeting Emotional Well-being in Healthy Adults: 4-Week Randomized Controlled Trial.JMIR mental health · 2023Article
- Associations of psychological wellbeing with COVID-19 hospitalization and mortality in adults aged 50 years or older from 25 European countries and Israel.Frontiers in public health · 2023Article
- Child and adolescent mental well-being intervention programme: A systematic review of randomised controlled trials.Frontiers in psychiatry · 2023Article
- Validation of a novel method of ultraviolet-induced cutaneous inflammation and its associations with anhedonia.Scientific reports · 2022Article
- Perceived mental health impacts of the COVID-19 pandemic: The roles of social support and social engagement for working age adults in the United States.Preventive medicine · 2022Article
- Life Satisfaction Prevents Decline in Working Memory, Spatial Cognition, and Processing Speed: Latent Change Score Analyses Across 23 Years.European psychiatry : the journal of the Association of European Psychiatrists · 2022Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
objectivesThere is a large literature linking inflammation with mental ill health, but a much smaller literature focusing on mental wellbeing. Specifically, it remains unclear whether mental wellbeing is longitudinally and independently associated with inflammation or only via associated changes in mental ill health.
methodsThis study used data from 8780 adults aged 50+ in the English Longitudinal Study of Ageing. Hedonic wellbeing (both positive affect and life satisfaction) and eudemonic wellbeing (self-realisation and control-autonomy) were measured at data collection waves 2 (2004/05), 4 (2008/09) and 6 (20012/13), along with measures of C-reactive protein (CRP), fibrinogen and white blood cells (WBC). Fixed effects modelling was performed to identify the longitudinal relationship between wellbeing and inflammation, adjusting for time-varying mental ill health and other identified confounders.
resultsBoth measured aspects of hedonic wellbeing were associated with lower WBC count, independent of mental ill health. For life satisfaction, this relationship was explained by confounders, whilst for positive affect it persisted. Both measured aspects of eudemonic wellbeing were associated with lower CRP, fibrinogen and WBC, independent of mental ill health. For control-autonomy, this relationship was explained by confounders, whilst for self-realisation it persisted. Results were present in both men and women, although more strongly in men, and were robust to a range of sensitivity analyses.
conclusionsThis study builds on the strong literature showing a relationship between mental ill health and inflammation by showing that there is also an apparently independent relationship between mental wellbeing, in particular eudemonic wellbeing, and inflammation that is unexplained by socio-economic or other time-constant factors and in some instances persists independent of time-varying confounders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.