ReviewNeuroImage2020
Distinguishing pain from nociception, salience, and arousal: How autonomic nervous system activity can improve neuroimaging tests of specificity.
Review in NeuroImage, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Comparison between Analgesia Nociception Index (ANI) and self-reported measures for diagnosing pain in conscious individuals: a systematic review and meta-analysis.Scientific reports · 2022Pooled it
- Effect of acupuncture on brain regions modulation of mild cognitive impairment: A meta-analysis of functional magnetic resonance imaging studies.Frontiers in aging neuroscience · 2022Pooled it
- Effects of Chronic Pain Treatment on Altered Functional and Metabolic Activities in the Brain: A Systematic Review and Meta-Analysis of Functional Neuroimaging Studies.Frontiers in neuroscience · 2021Pooled it
- Salience Network Dynamics Across Spontaneous Attacks, Interictal Rest and Interictal Pain Imagery in Menstrually Related Migraine.Brain topography · 2026Article
- Surgical Pleth Index as a Potentially Useful and Noninvasive Tool for Assessing Tracheal Intubation Conditions in Female Patients During Neuromuscular Blockade-Free Anesthesia.Emergency medicine international · 2026Article
- A Replicable and Generalizable Neuroimaging-Based Indicator of Pain Sensitivity Across Individuals.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Do some people with a prolonged disorder of consciousness experience pain? A clinically focused narrative review and synthesis.Clinical rehabilitation · 2025Review
- Pain integration of multimodal noxious stimulation based on the perceptual instruction.Proceedings. Biological sciences · 2025Article
- Nature exposure induces analgesic effects by acting on nociception-related neural processing.Nature communications · 2025Article
- Heart rate variability: A primer for alcohol researchers.Alcohol (Fayetteville, N.Y.) · 2024Article
- Explainable fNIRS-based pain decoding under pharmacological conditions via deep transfer learning approach.Neurophotonics · 2024Article
- Machines, mathematics, and modules: the potential to provide real-time metrics for pain under anesthesia.Neurophotonics · 2024Article
- Reliability of task-based fMRI in the dorsal horn of the human spinal cord.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Tactile acuity improves during acute experimental pain of the limb.Pain reports · 2023Article
- Priming of the autonomic nervous system after an experimental human pain model.Journal of neurophysiology · 2023Article
- I Feel! Therefore, I Am from Pain to Consciousness in DOC Patients.International journal of molecular sciences · 2023Review
- How Instructions, Learning, and Expectations Shape Pain and Neurobiological Responses.Annual review of neuroscience · 2023Review
- A Comparison of Functional Connectivity in the Human Brainstem and Spinal Cord Associated with Noxious and Innocuous Thermal Stimulation Identified by Means of Functional MRI.Brain sciences · 2023Article
- Noninvasive characterization of peripheral sympathetic activation across sensory stimuli using a peripheral arterial stiffness index.Frontiers in physiology · 2023Article
- Assessment and management of pain/nociception in patients with disorders of consciousness or locked-in syndrome: A narrative review.Frontiers in systems neuroscience · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Pain is a subjective, multidimensional experience that is distinct from nociception. A large body of work has focused on whether pain processing is supported by specific, dedicated brain circuits. Despite advances in human neuroscience and neuroimaging analysis, dissociating acute pain from other sensations has been challenging since both pain and non-pain stimuli evoke salience and arousal responses throughout the body and in overlapping brain circuits. In this review, we discuss these challenges and propose that brain-body interactions in pain can be leveraged in order to improve tests for pain specificity. We review brain and bodily responses to pain and nociception and extant efforts toward identifying pain-specific brain networks. We propose that autonomic nervous system activity should be used as a surrogate measure of salience and arousal to improve these efforts and enable researchers to parse out pain-specific responses in the brain, and demonstrate the feasibility of this approach using example fMRI data from a thermal pain paradigm. This new approach will improve the accuracy and specificity of functional neuroimaging analyses and help to overcome current difficulties in assessing pain specific responses in the human brain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.