Evidence map›Paper›PMID 31604032›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2020

Rifampicin, not vitamin E, suppresses parenteral nutrition-associated liver disease development through the pregnane X receptor pathway in piglets.

Gregory Guthrie, Barbara Stoll, Shaji Chacko, Charlotte Lauridsen, Jogchum Plat, Douglas Burrin

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Beyond lipids: Novel mechanisms for parenteral nutrition-associated liver disease.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2022
    Review
  8. Article
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Gregory GuthrieUnited States Department of Agriculture Agricultural Research Service, Children's Nutrition Research Center, Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
Barbara StollUnited States Department of Agriculture Agricultural Research Service, Children's Nutrition Research Center, Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
Shaji ChackoUnited States Department of Agriculture Agricultural Research Service, Children's Nutrition Research Center, Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
Charlotte LauridsenDepartment of Animal Science, Aarhus University, Tjele, Denmark.
Jogchum PlatDepartment of Nutrition and Movement Sciences, School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.
Douglas BurrinUnited States Department of Agriculture Agricultural Research Service, Children's Nutrition Research Center, Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.ORCID 0000-0002-8792-3339
Agricultural Research Service · USAarhus University · DKMaastricht University · NL

Funding

Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI James Versalovic · 2001 to 2026
$28.3M
Research Training in Pediatrics GastroenterolgyT32DK007664 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI DOUGLAS G BURRIN · 1991 to 2026
$8.4M
Regulation of Hepatic Metabolic Function by Parenteral NutritionR01DK094616 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI BURRIN, DOUGLAS G · 2013 to 2022
$2.3M
NIDDK NIH HHS P30 DK056338NIDDK NIH HHS R01 DK094616NIDDK NIH HHS T32 DK007664
6 · The paper itself

Abstract

Infants receiving long-term parenteral nutrition (PN) develop PN-associated liver disease (PNALD). We previously (Ng K et al.

Indexed as

Fat Emulsions, IntravenousParenteral NutritionPhospholipidsSoybean OilAnimalsAnimals, NewbornBile Acids and SaltsCholestasisCytochrome P-450 CYP3ADisease Models, AnimalEmulsionsGlucuronosyltransferaseHyperbilirubinemiaLiverLiver DiseasesPregnane X ReceptorBile Acids and SaltsCytochrome P-450 CYP3AEmulsionsFat Emulsions, IntravenousGlucuronosyltransferasePhospholipidsPregnane X ReceptorRifampinSoybean Oilsoybean oil, phospholipid emulsionVitamin Ebile acid metabolismcholestasisparenteral nutrition-associated liver diseaserifampicinvitamin Eα-tocopherol

Identifiers

PMID31604032
PMCPMC6985848
OpenAlexW2979493661

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.