Evidence map›Paper›PMID 31604031›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2020

Richard A Jacobson, Kiedo Wienholts, Ashley J Williamson, Sara Gaines, Sanjiv Hyoju, Harry van Goor, Alexander Zaborin, Benjamin D Shogan, Olga Zaborina, John C Alverdy

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 3 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Review
  7. Modulation of the gut microbiota as a novel strategy to prevent anastomotic leak after colorectal surgery: Systematic scoping review.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2026
    Article
  8. The perioperative microbiome of patients undergoing rectal cancer surgery: A pilot study.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2026
    Article
  9. Article
  10. Review
  11. Article
  12. CollagenolyticSurgery open science · 2025
    Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Abdominal fascia dehiscence: is there a connection to a special microbial spectrum?Hernia : the journal of hernias and abdominal wall surgery · 2023
    Article
  19. Article
  20. The implication of gut microbiota in recovery from gastrointestinal surgery.Frontiers in cellular and infection microbiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Richard A JacobsonDepartment of Surgery, Rush University Medical Center, Chicago, Illinois.ORCID 0000-0002-3432-5378
Kiedo WienholtsRadboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Ashley J WilliamsonPritzker School of Medicine, University of Chicago, Illinois.
Sara GainesPritzker School of Medicine, University of Chicago, Illinois.
Sanjiv HyojuPritzker School of Medicine, University of Chicago, Illinois.
Harry van GoorRadboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Alexander ZaborinPritzker School of Medicine, University of Chicago, Illinois.
Benjamin D ShoganPritzker School of Medicine, University of Chicago, Illinois.
Olga ZaborinaPritzker School of Medicine, University of Chicago, Illinois.
John C AlverdyPritzker School of Medicine, University of Chicago, Illinois.
University of Chicago · USRadboud University Nijmegen · NLRush University Medical Center · US

Funding

PSEUDOMONAS'EFFECTS ON THE GUT BARRIER FROM SURGERYR01GM062344 · NIGMS · UNIVERSITY OF CHICAGO · PI ALVERDY, JOHN C · 2001 to 2025
$9.2M
NIGMS NIH HHS R01 GM062344
6 · The paper itself

Abstract

Perforations, anastomotic leak, and subsequent intra-abdominal sepsis are among the most common and feared complications of invasive interventions in the colon and remaining intestinal tract. During physiological healing, tissue protease activity is finely orchestrated to maintain the strength and integrity of the submucosa collagen layer in the wound. We (Shogan, BD et al.

Indexed as

FibrinolysisWound HealingAnimalsAnti-Bacterial AgentsAntifibrinolytic AgentsCollagen Type ICollagen Type IVColonDisease Models, AnimalEnterococcus faecalisGram-Positive Bacterial InfectionsHost-Pathogen InteractionsHumansMice, Inbred C57BLPlasminogenProteolysisAnti-Bacterial AgentsAntifibrinolytic AgentsCollagen Type ICollagen Type IVPlasminogenTranexamic AcidUrokinase-Type Plasminogen ActivatorEnterococcus faecalisgastrointestinal healingplasminogen

Identifiers

PMID31604031
PMCPMC6985841
OpenAlexW2979531164

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.