Evidence map›Paper›PMID 31603999›Full record

SynthesisJournal of viral hepatitis2020

Prevalence and burden of HBV co-infection among people living with HIV: A global systematic review and meta-analysis.

Lucy Platt, Clare E French, Catherine R McGowan, Keith Sabin, Erin Gower, Adam Trickey, Bethan McDonald, Jason Ong, Jack Stone, Philippa Easterbrook and 1 more

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of viral hepatitis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

110 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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50 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lucy PlattFaculty of Public Health & Policy, London School of Hygiene & Tropical Medicine, London, UK.ORCID 0000-0002-0943-0045
Clare E FrenchNIHR Health Protection Research Unit in Evaluation of Interventions, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.ORCID 0000-0002-6943-7353
Catherine R McGowanFaculty of Public Health & Policy, London School of Hygiene & Tropical Medicine, London, UK.
Keith SabinUNAIDS, Geneva, Switzerland.ORCID 0000-0002-2290-8621
Erin GowerCentre for Disease Control and Prevention, Atlanta, USA.
Adam TrickeyNIHR Health Protection Research Unit in Evaluation of Interventions, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.ORCID 0000-0003-3462-2898
Bethan McDonaldOxford School of Public Health, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Jason OngDepartment of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK.
Jack StoneNIHR Health Protection Research Unit in Evaluation of Interventions, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Philippa EasterbrookWorld Health Organisation, Geneva, Switzerland.ORCID 0000-0002-2603-5418
Peter VickermanNIHR Health Protection Research Unit in Evaluation of Interventions, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.ORCID 0000-0002-8291-5890

Funding

Department of Health 12/3070/13World Health Organization 001
6 · The paper itself

Abstract

Globally, in 2017 35 million people were living with HIV (PLHIV) and 257 million had chronic HBV infection (HBsAg positive). The extent of HIV-HBsAg co-infection is unknown. We undertook a systematic review to estimate the global burden of HBsAg co-infection in PLHIV. We searched MEDLINE, Embase and other databases for published studies (2002-2018) measuring prevalence of HBsAg among PLHIV. The review was registered with PROSPERO (#CRD42019123388). Populations were categorized by HIV-exposure category. The global burden of co-infection was estimated by applying regional co-infection prevalence estimates to UNAIDS estimates of PLHIV. We conducted a meta-analysis to estimate the odds of HBsAg among PLHIV compared to HIV-negative individuals. We identified 506 estimates (475 studies) of HIV-HBsAg co-infection prevalence from 80/195 (41.0%) countries. Globally, the prevalence of HIV-HBsAg co-infection is 7.6% (IQR 5.6%-12.1%) in PLHIV, or 2.7 million HIV-HBsAg co-infections (IQR 2.0-4.2). The greatest burden (69% of cases; 1.9 million) is in sub-Saharan Africa. Globally, there was little difference in prevalence of HIV-HBsAg co-infection by population group (approximately 6%-7%), but it was slightly higher among people who inject drugs (11.8% IQR 6.0%-16.9%). Odds of HBsAg infection were 1.4 times higher among PLHIV compared to HIV-negative individuals. There is therefore, a high global burden of HIV-HBsAg co-infection, especially in sub-Saharan Africa. Key prevention strategies include infant HBV vaccination, including a timely birth-dose. Findings also highlight the importance of targeting PLHIV, especially high-risk groups for testing, catch-up HBV vaccination and other preventative interventions. The global scale-up of antiretroviral therapy (ART) for PLHIV using a tenofovir-based ART regimen provides an opportunity to simultaneously treat those with HBV co-infection, and in pregnant women to also reduce mother-to-child transmission of HBV alongside HIV.

Indexed as

CoinfectionCost of IllnessGlobal HealthHepatitis BHIV InfectionsHumansPrevalenceco-infectionhepatitis BHIVsystematic reviewviral hepatitis

Identifiers

PMID31603999
PMCPMC7383613

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.