ArticlePloS one2019
Large-scale phylogenomic analysis suggests three ancient superclades of the WUSCHEL-RELATED HOMEOBOX transcription factor family in plants.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Early "Rootprints" of Plant Terrestrialization: Selaginella Root Development Sheds Light on Root Evolution in Vascular Plants.Frontiers in plant science · 2021Pooled it
- Newly found functions and regulatory networks of WOX family: what else does the WOX say?Planta · 2026Review
- Genome-Wide Identification of theInternational journal of molecular sciences · 2026Article
- Genome-wide identification and expression analysis of the maize ZmWOX gene family reveal its critical role in callus formation.BMC genomics · 2026Article
- Genome-Wide Identification and Expression Analysis of the WOX Family Reveals Potential Roles in Stem Development ofPlants (Basel, Switzerland) · 2026Article
- Article
- Transcription Factor Analysis of Rhodophytes Suggests Trihelix Transcription Factors Across the Florideophyceae.Plants (Basel, Switzerland) · 2025Article
- Genomic Features and Predicted 3D Structures of the CcWOX Transcription Factors inInternational journal of molecular sciences · 2025Article
- Diversification of CLE expression patterns and nonmeristematic roles for CLAVATA receptor-like kinases in a moss.The New phytologist · 2025Article
- Evolutionary Insight and Expression Pattern of WUSCHEL-Related Homebox Genes ofFood science & nutrition · 2025Article
- Transcriptome-wide identification and characterization of WUSCHEL-related homeobox (WOX) gene family in Pinus yunnanensis.BMC genomics · 2025Article
- The rise of CLAVATA: evidence for CLAVATA3 and WOX signaling in the fern gametophyte.The Plant journal : for cell and molecular biology · 2025Article
- Transcriptome-wide identification of the WUSCHEL-related homeobox transcription factors and their expression patterns underlying drought and salt stress inFrontiers in plant science · 2025Article
- Unlocking regeneration potential: harnessing morphogenic regulators and small peptides for enhanced plant engineering.The Plant journal : for cell and molecular biology · 2025Review
- Article
- Plant Growth Regulators: An Overview of WOX Gene Family.Plants (Basel, Switzerland) · 2024Review
- Cytokinin and ALOG proteins regulate pluripotent stem cell identity in the mossScience advances · 2024Article
- WOX2 functions redundantly with WOX1 and WOX4 to positively regulate seed germination in Arabidopsis.Planta · 2024Article
- ThePlants (Basel, Switzerland) · 2024Article
- A Comprehensive Identification and Expression Analysis of the WUSCHEL Homeobox-Containing Protein Family Reveals Their Special Role in Development and Abiotic Stress Response inInternational journal of molecular sciences · 2023Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The adaptation of plants to land required multiple morphological innovations. Among these include a variety of lateral organs that are initiated from apical meristems, in which the mantainance of undifferentiated stem cells is regulated by the homeodomain WUSCHEL-RELATED (WOX) transcription factors. Expansion of the WOX gene family has been associated with whole genome duplication (WGD) events and postulated to have been pivotal to the evolution of morphological complexity in land plants. Previous studies have classified the WOX gene family into three superclades (e.g., the ancient clade, the intermediate clade, and the modern clade). In order to improve our understanding of the evolution of the WOX gene family, we surveyed the WOX gene sequences from 38 genomes and 440 transcriptomes spanning the Viridiplantae and Rhodophyta. The WOX phylogeny inferred from 1039 WOX proteins drawn from 267 species with improved support along the backbone of the phylogeny suggests that the plant-specific WOX family contains three ancient superclades, which we term Type 1 (T1WOX, the WOX10/13/14 clade), Type 2 (T2WOX, the WOX8/9 and WOX11/12 clades), and Type 3 (T3WOX, the WUS, WOX1/6, WOX2, WOX3, WOX4 and WOX5/7 clades). Divergence of the T1WOX and T2WOX superclades may predate the diversification of vascular plants. Synteny analysis suggests contribution of WGD to expansion of the WOX family. Promoter analysis finds that the capacity of the WOX genes to be regulated by the auxin and cytokinin signaling pathways may be deeply conserved in the Viridiplantae. This study improves our phylogenetic context for elucidating functional evolution of the WOX gene family, which has likely contributed to the morphological complexity of land plants.
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