Evidence map›Paper›PMID 31603914›Full record

Trial reportPloS one2019

The effectiveness of a community-based, type 2 diabetes prevention programme on health-related quality of life. The DE-PLAN study.

Georgios Karamanakos, Bernardo Costa-Pinel, Aleksandra Gilis-Januszewska, Dzilda Velickiene, Francisco Barrio-Torrell, Xavier Cos-Claramunt, Santiago Mestre-Miravet, Beata Piwońska-Solska, Alicja Hubalewska-Dydejczyk, Jaakko Tuomilehto and 2 more

Registry-linked trialAbstract readClinical TrialMulticenter StudyValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04489043 (Exercise, Prediabetes and Diabetes After Renal Transplantation.), which is not on this map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04489043 naunknown statusnot on this map

Exercise, Prediabetes and Diabetes After Renal Transplantation.

TypeinterventionalSponsorHospital Universitario de CanariasRan2019 to 2021Enrolled60ConditionsDiabetes MellitusArmsExercise and healthy lifestyle recommendations
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  3. The effect of a community-based health behaviour intervention on health-related quality of life in people with Type 2 diabetes in Nepal: a Cluster Randomized Controlled Trial.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Georgios KaramanakosFirst Department of Propaedeutic Medicine, Diabetes Center, National and Kapodistrian University of Athens, Laiko General Hospital, Athens, Greece.ORCID 0000-0002-8870-6475
Bernardo Costa-PinelCatalan Diabetes Prevention Research Group, Jordi Gol Primary Care Research Institute, Catalan Health Institute, Primary Health Care Division, Reus-Barcelona, Spain.
Aleksandra Gilis-JanuszewskaDepartment of Endocrinology, Jagiellonian University, Medical College, Krakow, Poland.
Dzilda VelickieneLithuanian University of Health Sciences, Institute of Endocrinology, Kaunas, Lithuania, LT.
Francisco Barrio-TorrellCatalan Diabetes Prevention Research Group, Jordi Gol Primary Care Research Institute, Catalan Health Institute, Primary Health Care Division, Reus-Barcelona, Spain.
Xavier Cos-ClaramuntCatalan Diabetes Prevention Research Group, Jordi Gol Primary Care Research Institute, Catalan Health Institute, Primary Health Care Division, Reus-Barcelona, Spain.
Santiago Mestre-MiravetCatalan Diabetes Prevention Research Group, Jordi Gol Primary Care Research Institute, Catalan Health Institute, Primary Health Care Division, Reus-Barcelona, Spain.
Beata Piwońska-SolskaDepartment of Endocrinology, Jagiellonian University, Medical College, Krakow, Poland.
Alicja Hubalewska-DydejczykDepartment of Endocrinology, Jagiellonian University, Medical College, Krakow, Poland.
Jaakko TuomilehtoDepartment of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland.
Stavros LiatisFirst Department of Propaedeutic Medicine, Diabetes Center, National and Kapodistrian University of Athens, Laiko General Hospital, Athens, Greece.
Konstantinos MakrilakisFirst Department of Propaedeutic Medicine, Diabetes Center, National and Kapodistrian University of Athens, Laiko General Hospital, Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsThe DE-PLAN was a European multicenter study, with the primary objective of testing whether a community-based lifestyle modification programme could serve as a means of primary prevention for type 2 diabetes (T2D) in high-risk individuals (based on the FINDRISC questionnaire). The aim of this study was to examine the impact of a 1-year community-based lifestyle intervention on health-related quality of life (HRQOL) in individuals from four participating European centers (Athens, Barcelona, Krakow, Kaunas), through a post-hoc analysis. MATERIALS AND

methodsEach center was allowed to implement different intervention strategies specifically tailored to the needs of their corresponding population sample. Before and after the intervention, participants underwent clinical evaluation, anthropometric measurements, an oral glucose tolerance test and lipid profile measurements. Health-related quality of life was assessed using the validated HRQOL-15D questionnaire. A difference of ±0.015 in the 15D questionnaire score was set as the threshold of clinically meaningful change.

resultsData from 786 participants (67% females, mean age 59.7±9.4 years, BMI 31.5±4.5 kg/m2) with complete data regarding the HRQOL were analyzed (Athens: 104, Barcelona: 434, Krakow: 175, Kaunas: 70). After 1 year, a significant overall improvement in HRQOL was shown, as depicted by a change of 15D score from baseline value (0.88±0.9) to post-intervention (0.90±0.87, P<0.001), achieving the threshold of clinically meaningful change. A significant weight reduction was also observed (-0.8±4.0 kg, P<0.001). In multivariate analysis, improvement in HRQOL was independently associated with lower 15D score at baseline (P<0.001) and self-reported increase in overall exercise time (P<0.001) as assessed through specifically designed trial questionnaires.

conclusionA community-based lifestyle intervention programme aiming at T2D prevention, applied on a heterogeneous population and with varied methods, was shown to improve overall health-related quality of life to a clinically meaningful degree.

Indexed as

Quality of LifeRisk Reduction BehaviorSurveys and QuestionnairesAgedDiabetes Mellitus, Type 2FemaleHumansMaleMiddle AgedPublic Health

Identifiers

PMID31603914
PMCPMC6788719

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.