Evidence map›Paper›PMID 31603681›Full record

ArticleJournal of medicinal chemistry2019

Structure-Activity Relationship Studies To Identify Affinity Probes in Bis-aryl Sulfonamides That Prolong Immune Stimuli.

Michael Chan, Fitzgerald S Lao, Paul J Chu, Jonathan Shpigelman, Shiyin Yao, Jason Nan, Fumi Sato-Kaneko, Vicky Li, Tomoko Hayashi, Maripat Corr and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Mitochondria-dependent synthetic small-molecule vaccine adjuvants for influenza virus infection.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Michael ChanMoores Cancer Center , University of California, San Diego , La Jolla , California 92093-0695 , United States.
Fitzgerald S LaoMoores Cancer Center , University of California, San Diego , La Jolla , California 92093-0695 , United States.
Paul J ChuMoores Cancer Center , University of California, San Diego , La Jolla , California 92093-0695 , United States.
Jonathan ShpigelmanMoores Cancer Center , University of California, San Diego , La Jolla , California 92093-0695 , United States.
Shiyin YaoMoores Cancer Center , University of California, San Diego , La Jolla , California 92093-0695 , United States.
Jason NanMoores Cancer Center , University of California, San Diego , La Jolla , California 92093-0695 , United States.
Fumi Sato-KanekoMoores Cancer Center , University of California, San Diego , La Jolla , California 92093-0695 , United States.
Vicky LiMoores Cancer Center , University of California, San Diego , La Jolla , California 92093-0695 , United States.
Tomoko HayashiMoores Cancer Center , University of California, San Diego , La Jolla , California 92093-0695 , United States.
Maripat CorrDepartment of Medicine , University of California, San Diego , La Jolla , California 92093 , United States.
Dennis A CarsonMoores Cancer Center , University of California, San Diego , La Jolla , California 92093-0695 , United States.
Howard B CottamMoores Cancer Center , University of California, San Diego , La Jolla , California 92093-0695 , United States.ORCID 0000-0001-7382-0585
Nikunj M ShuklaMoores Cancer Center , University of California, San Diego , La Jolla , California 92093-0695 , United States.ORCID 0000-0002-5150-7827
University of California San Diego · US

Funding

NIAID NIH HHS HHSN272200900034CNIAID NIH HHS HHSN272201400051C
6 · The paper itself

Abstract

Agents that safely induce, enhance, or sustain multiple innate immune signaling pathways could be developed as potent vaccine adjuvants or coadjuvants. Using high-throughput screens with cell-based nuclear factor κB (NF-κB) and interferon stimulating response element (ISRE) reporter assays, we identified a bis-aryl sulfonamide bearing compound

Indexed as

BenzeneCell LineHumansImmunologic FactorsKineticsNF-kappa BStructure-Activity RelationshipSulfonamidesBenzeneImmunologic FactorsNF-kappa BSulfonamides

Identifiers

PMID31603681
PMCPMC8992017
OpenAlexW2979508077

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.