Evidence map›Paper›PMID 31603679›Full record

ArticleJournal of the American Chemical Society2019

Installation of Minimal Tetrazines through Silver-Mediated Liebeskind-Srogl Coupling with Arylboronic Acids.

William D Lambert, Yinzhi Fang, Subham Mahapatra, Zhen Huang, Christopher W Am Ende, Joseph M Fox

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 66 citations in OpenAlex.

  1. Article
  2. Article
  3. Synthesis of CThe Journal of organic chemistry · 2024
    Article
  4. Article
  5. Review
  6. Article
  7. Minimalist TetrazineJournal of the American Chemical Society · 2024
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Bioorthogonal chemistry.Nature reviews. Methods primers · 2021
    Article
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

William D LambertDepartment of Chemistry and Biochemistry , University of Delaware , Newark , Delaware 19716 , United States.
Yinzhi FangDepartment of Chemistry and Biochemistry , University of Delaware , Newark , Delaware 19716 , United States.
Subham MahapatraPfizer Worldwide Research and Development , Eastern Point Road , Groton , Connecticut 06340 , United States.
Zhen HuangPfizer Worldwide Research and Development , 1 Portland Street , Cambridge , Massachusetts 02139 , United States.
Christopher W Am EndePfizer Worldwide Research and Development , Eastern Point Road , Groton , Connecticut 06340 , United States.ORCID 0000-0001-8832-9641
Joseph M FoxDepartment of Chemistry and Biochemistry , University of Delaware , Newark , Delaware 19716 , United States.ORCID 0000-0002-8258-1640
Pfizer (United States) · USUniversity of Delaware · US

Funding

This renovation project will create over 1455 sq. ft. of state- of-the-art reseaP20GM104316 · NIGMS · UNIVERSITY OF DELAWARE · PI SCHMITZ, KARL ROBERT · 2014 to 2024
$26.8M
Pilot Research Subproject ProgramP30GM110758 · NIGMS · UNIVERSITY OF DELAWARE · PI PATEL, SANDEEP · 2014 to 2018
$5.8M
Toolkit for Fast, Multipurpose and Inducible Bioorthogonal ChemistryR01GM132460 · NIGMS · UNIVERSITY OF DELAWARE · PI JOSEPH M FOX · 2019 to 2026
$4.2M
Q-Exactive Orbitrap LC-MC/MS SystemS10OD016267 · OD · UNIVERSITY OF DELAWARE · PI JOHNSTON, MURRAY V · 2013 to 2013
$573k
High Performance Digital NMR SpectrometerS10RR026962 · NCRR · UNIVERSITY OF DELAWARE · PI FOX, JOSEPH M · 2010 to 2010
$500k
NCRR NIH HHS S10 RR026962NIGMS NIH HHS P20 GM104316NIGMS NIH HHS P30 GM110758NIGMS NIH HHS R01 GM132460NIH HHS S10 OD016267
6 · The paper itself

Abstract

Described is a general method for the installation of a minimal 6-methyltetrazin-3-yl group via the first example of a Ag-mediated Liebeskind-Srogl cross-coupling. The attachment of bioorthogonal tetrazines on complex molecules typically relies on linkers that can negatively impact the physiochemical properties of conjugates. Cross-coupling with arylboronic acids and a new reagent, 3-((

Indexed as

BenzodioxolesBoron CompoundsBoronic AcidsBrainCalorimetry, Differential ScanningCatalysisCopperFluorescent DyesHeterocyclic Compounds, 1-RingHumansMolecular ProbesMonoacylglycerol LipasesPiperidinesSilver1,1,1,3,3,3-hexafluoropropan-2-yl 4-(bis(benzo(d)(1,3)dioxol-5-yl)(hydroxy)methyl)piperidine-1-carboxylate4,4-difluoro-4-bora-3a,4a-diaza-s-indaceneBenzodioxolesBoron CompoundsBoronic AcidsCopperFluorescent DyesHeterocyclic Compounds, 1-RingMolecular ProbesMonoacylglycerol LipasesPiperidinesSilver

Identifiers

PMID31603679
PMCPMC6925384
OpenAlexW2979620700

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.