Evidence map›Paper›PMID 31603669›Full record

ArticleJournal of medicinal chemistry2019

Novel Matrix Metalloproteinase 12 Selective Radiotracers for Vascular Molecular Imaging.

Jakub Toczek, Thomas Bordenave, Kiran Gona, Hye-Yeong Kim, Fabrice Beau, Dimitris Georgiadis, Isabelle Correia, Yunpeng Ye, Mahmoud Razavian, Jae-Joon Jung and 4 more

Open access · greenAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Evaluation of cardiac allograft vasculopathy by positron emission tomography.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021
    Review
  6. Review
  7. Mechanisms of Proteolytic Enzymes and Their Inhibition in QM/MM Studies.International journal of molecular sciences · 2021
    Review
  8. Article
  9. Current and novel radiopharmaceuticals for imaging cardiovascular inflammation.The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of... · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Jakub ToczekCardiovascular Molecular Imaging Laboratory, Section of Cardiovascular Medicine and Yale Cardiovascular Research Center , Yale University School of Medicine , New Haven , Connecticut 06511 , United States.
Thomas BordenaveCEA, Institut des Sciences du Vivant Frédéric Joliot, Service d'Ingénierie Moléculaire des Protéines (SIMOPRO), Université Paris-Saclay , Gif-sur-Yvette 91190 , France.
Kiran GonaCardiovascular Molecular Imaging Laboratory, Section of Cardiovascular Medicine and Yale Cardiovascular Research Center , Yale University School of Medicine , New Haven , Connecticut 06511 , United States.
Hye-Yeong KimCardiovascular Molecular Imaging Laboratory, Section of Cardiovascular Medicine and Yale Cardiovascular Research Center , Yale University School of Medicine , New Haven , Connecticut 06511 , United States.ORCID 0000-0001-9081-8487
Fabrice BeauCEA, Institut des Sciences du Vivant Frédéric Joliot, Service d'Ingénierie Moléculaire des Protéines (SIMOPRO), Université Paris-Saclay , Gif-sur-Yvette 91190 , France.
Dimitris GeorgiadisLaboratory of Organic Chemistry, Department of Chemistry , University of Athens , Panepistimiopolis Zografou, 15771 Athens , Greece.ORCID 0000-0002-9656-0701
Isabelle CorreiaSorbonne Université, Ecole Normale Supérieure, PSL University, CNRS, Laboratoire des Biomolécules, LBM , 75005 Paris , France.
Yunpeng YeCardiovascular Molecular Imaging Laboratory, Section of Cardiovascular Medicine and Yale Cardiovascular Research Center , Yale University School of Medicine , New Haven , Connecticut 06511 , United States.
Mahmoud RazavianCardiovascular Molecular Imaging Laboratory, Section of Cardiovascular Medicine and Yale Cardiovascular Research Center , Yale University School of Medicine , New Haven , Connecticut 06511 , United States.
Jae-Joon JungCardiovascular Molecular Imaging Laboratory, Section of Cardiovascular Medicine and Yale Cardiovascular Research Center , Yale University School of Medicine , New Haven , Connecticut 06511 , United States.
Olivier LequinSorbonne Université, Ecole Normale Supérieure, PSL University, CNRS, Laboratoire des Biomolécules, LBM , 75005 Paris , France.ORCID 0000-0001-5307-3068
Vincent DiveCEA, Institut des Sciences du Vivant Frédéric Joliot, Service d'Ingénierie Moléculaire des Protéines (SIMOPRO), Université Paris-Saclay , Gif-sur-Yvette 91190 , France.
Mehran M SadeghiCardiovascular Molecular Imaging Laboratory, Section of Cardiovascular Medicine and Yale Cardiovascular Research Center , Yale University School of Medicine , New Haven , Connecticut 06511 , United States.ORCID 0000-0002-5074-3510
Laurent DevelCEA, Institut des Sciences du Vivant Frédéric Joliot, Service d'Ingénierie Moléculaire des Protéines (SIMOPRO), Université Paris-Saclay , Gif-sur-Yvette 91190 , France.ORCID 0000-0002-4464-5826
Yale University · USCommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRCentre National de la Recherche Scientifique · FRNational and Kapodistrian University of Athens · GR

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Novel Regulators of Calcific Aortic Valve DiseaseR01HL138567 · NHLBI · YALE UNIVERSITY · PI SADEGHI, MEHRAN M · 2017 to 2020
$2.8M
Macrophage elastase and its imaging in vascular inflammation and remodelingR01HL112992 · NHLBI · YALE UNIVERSITY · PI SADEGHI, MEHRAN M · 2013 to 2016
$2.0M
Mechanistic studies of disease progression in aortic aneurysmsI01BX004038 · VA · VA CONNECTICUT HEALTHCARE SYSTEM · PI SADEGHI, MEHRAN M · 2019 to 2022
–
BLRD VA I01 BX004038NCATS NIH HHS UL1 TR001863NHLBI NIH HHS R01 HL112992NHLBI NIH HHS R01 HL138567
6 · The paper itself

Abstract

Matrix metalloproteinase-12 (MMP-12) is highly upregulated in several inflammatory diseases, including abdominal aortic aneurysm (AAA). Here we report four novel

Indexed as

AnimalsAortaAortic Aneurysm, AbdominalHumansMaleMatrix Metalloproteinase 12Matrix Metalloproteinase InhibitorsMiceMice, Inbred C57BLMolecular ImagingOrganotechnetium CompoundsRadioactive TracersRadiochemistryTissue DistributionUp-RegulationMatrix Metalloproteinase 12Matrix Metalloproteinase InhibitorsOrganotechnetium CompoundsRadioactive Tracers

Identifiers

PMID31603669
PMCPMC7054845
OpenAlexW2979651555

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.