ArticleMolecular plant pathology2019
A conserved GH17 glycosyl hydrolase from plant pathogenic Dothideomycetes releases a DAMP causing cell death in tomato.
Article in Molecular plant pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 42 citations in OpenAlex.
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- A β-1,3-glucanase antagonizes a phase-separating WRKY repressor to confer saline-alkaline tolerance in rice.The New phytologist · 2026Article
- Integrated taxonomy and genomic analysis of Marssonina zanthoxyli, the causal agent of prickly ash leaf defoliation.BMC genomics · 2026Article
- Glycoside Hydrolase CaGH17-12 Contributes to Phytophthora Blight Resistance by Activating the Production of Reactive Oxygen Species and Jasmonic Acid Signalling in Pepper.Molecular plant pathology · 2026Article
- Glycoside Hydrolase Family 16 Enzyme RsEG146 From Rhizoctonia solani AG1 IA Induces Cell Death and Triggers Defence Response in Nicotiana tabacum.Molecular plant pathology · 2025Article
- Genome-Wide Identification, Expression and Interaction Analysis ofCurrent issues in molecular biology · 2024Article
- Infection ofJournal of fungi (Basel, Switzerland) · 2024Article
- Plant immunity suppression by an β-1,3-glucanase of the maize anthracnose pathogen Colletotrichum graminicola.BMC plant biology · 2024Article
- A Glycosyl Hydrolase 5 Family Protein Is Essential for Virulence of Necrotrophic Fungi and Can Suppress Plant Immunity.International journal of molecular sciences · 2024Article
- The Dynamic Interaction between Oil Palm andJournal of fungi (Basel, Switzerland) · 2024Article
- Transcriptome analysis ofFrontiers in microbiology · 2024Article
- Functional genomics identifies a small secreted protein that plays a role during the biotrophic to necrotrophic shift in the root rot pathogenFrontiers in plant science · 2024Article
- An Ustilaginoidea virens glycoside hydrolase 42 protein is an essential virulence factor and elicits plant immunity as a PAMP.Molecular plant pathology · 2023Article
- Plant immunity suppression by an exo-β-1,3-glucanase and an elongation factor 1α of the rice blast fungus.Nature communications · 2023Article
- The Rice Endophyte-Derived α-Mannosidase ShAM1 Degrades Host Cell Walls To Activate DAMP-Triggered Immunity against Disease.Microbiology spectrum · 2023Article
- Beyond the genomes of Fulvia fulva (syn. Cladosporium fulvum) and Dothistroma septosporum: New insights into how these fungal pathogens interact with their host plants.Molecular plant pathology · 2023Review
- Insights into the genomic evolution and the alkali tolerance mechanisms ofMicrobial genomics · 2023Article
- RNA silencing proteins and small RNAs in oomycete plant pathogens and biocontrol agents.Frontiers in microbiology · 2023Article
- A conserved enzyme of smut fungi facilitates cell-to-cell extension in the plant bundle sheath.Nature communications · 2022Article
- Unveiling the Core Effector Proteins of Oil Palm PathogenJournal of fungi (Basel, Switzerland) · 2022Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
To facilitate infection, pathogens deploy a plethora of effectors to suppress basal host immunity induced by exogenous microbe-associated or endogenous damage-associated molecular patterns (DAMPs). In this study, we have characterized family 17 glycosyl hydrolases of the tomato pathogen Cladosporium fulvum (CfGH17) and studied their role in infection. Heterologous expression of CfGH17-1 to 5 by potato virus X in different tomato cultivars showed that CfGH17-1 and CfGH17-5 enzymes induce cell death in Cf-0, Cf-1 and Cf-5 but not in Cf-Ecp3 tomato cultivars or tobacco. Moreover, CfGH17-1 orthologues from other phytopathogens, including Dothistroma septosporum and Mycosphaerella fijiensis, also trigger cell death in tomato. CfGH17-1 and CfGH17-5 are predicted to be β-1,3-glucanases and their enzymatic activity is required for the induction of cell death. CfGH17-1 hydrolyses laminarin, a linear 1,3-β-glucan with 1,6-β linkages. CfGH17-1 expression is down-regulated during the biotrophic phase of infection and up-regulated during the necrotrophic phase. Deletion of CfGH17-1 in C. fulvum did not reduce virulence on tomato, while constitutive expression of CfGH17-1 decreased virulence, suggesting that abundant presence of CfGH17-1 during biotrophic growth may release a DAMP that activates plant defence responses. Under natural conditions CfGH17-1 is suggested to play a role during saprophytic growth when the fungus thrives on dead host tissue, which is in line with its high levels of expression at late stages of infection when host tissues have become necrotic. We suggest that CfGH17-1 releases a DAMP from the host cell wall that is recognized by a yet unknown host plant receptor.
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