ArticleThe Laryngoscope2020
Outcomes in children with down syndrome and mild obstructive sleep apnea treated non-surgically.
Article in The Laryngoscope, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sleep disorders in Down syndrome: a systematic review.Arquivos de neuro-psiquiatria · 2022Pooled it
- Obstructive sleep apnea in children with Down syndrome: contribution of upper airway and chemosensitivity.Pediatric research · 2023Article
- Recent advances in paediatric sleep disordered breathing.Breathe (Sheffield, England) · 2022Review
- Treatment Considerations for Obstructive Sleep Apnea in Pediatric Down Syndrome.Children (Basel, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectivesNasal steroids, oral anti-leukotrienes and supplemental oxygen are effective in the treatment of mild obstructive sleep apnea (OSA) in otherwise healthy children. However, their efficacy is unknown in children with Down syndrome (DS). Here we examine the effect of single medication therapy versus observation versus oxygen on polysomnographic outcomes in these children.
methodsWe reviewed children (<18 years) diagnosed with DS and mild OSA (obstructive apnea-hypopnea index [oAHI] ≥1 to <5 events/hour) treated non-surgically (with supplemental oxygen, one medication, or observation) between 2012 and 2017. Demographic data, comorbid diagnoses, and pre- and posttreatment polysomnograms were analyzed. We assessed pre- and posttreatment oAHI, oxyhemoglobin saturation nadir, percent total sleep time (%TST) in rapid eye movement (REM), and end-tidal carbon dioxide (ETCO
resultsTwenty-four children met inclusion criteria; 10 treated with medication, one with oxygen, and 13 with observation (baseline oAHI was 3.5, 3.3, and 2.9 events/hour, respectively). There was no significant change in oAHI, oxyhemoglobin saturation nadir, ETCO
conclusionIn our cohort, resolution of mild OSA was low. This suggests that consideration should be given to multimodality treatments in children with DS and mild OSA. Prospective studies will help establish effectiveness in this cohort. LEVEL OF EVIDENCE: 4 Laryngoscope, 130:1828-1835, 2020.
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