SynthesisThe Journal of clinical endocrinology and metabolism2020
Prevalence of Insomnia (Symptoms) in T2D and Association With Metabolic Parameters and Glycemic Control: Meta-Analysis.
Synthesis in The Journal of clinical endocrinology and metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Health risk behaviours, mental health and HbA1c: an overview of reviews of observational studies.BMJ open · 2025Pooled it
- The association between insomnia (related symptoms) and glycaemic control: a systematic review and meta-analysis.Journal of global health · 2025Pooled it
- Sleep behaviours and associated habits and the progression of pre-diabetes to type 2 diabetes mellitus in adults: A systematic review and meta-analysis.Diabetes & vascular disease researchPooled it
- The effect of MIND diet on sleep status, mental health, and serum level of BDNF in overweight/obese diabetic women with insomnia: a randomized controlled trial.Scientific reports · 2025Trial
- Lack of Efficacy of Suvorexant in People with Insomnia and Poorly Controlled Type 2 Diabetes.Nature and science of sleep · 2023Trial
- Sleep Improvement for Metabolic Health: A Feasibility Trial of a Digital Sleep Treatment in People With Insomnia and Non-Diabetic Hyperglycaemia.Journal of sleep research · 2026Article
- The sleep-wake cycle: molecular mechanisms, disorders, and therapeutic targets in the context of energy metabolism.Signal transduction and targeted therapy · 2026Review
- Diabetes mellitus is associated with increased prevalence and severity of COMISA: evidence from the nationwide TURKAPNE cohort.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Observational
- Causal relationships between insomnia and blood metabolome: a Mendelian randomization study with mouse experimental validation.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- The Role of Circadian Rhythm Dysregulation, Abnormal Sleep Patterns, and Sleep Disorders on the Development of Diabetes.Clocks & sleep · 2026Review
- Role of Sleep Disturbances and Diabetes-Related Distress on Glycemic Control: A Path Analysis.Research in nursing & health · 2026Article
- Insomnia in Type 2 Diabetes Mellitus: Prevalence, Psychological Correlates, and Association With Glycemic Control.Cureus · 2026Article
- Factors associated with sleep duration in a Chinese middle-aged and elderly diabetic population: a cross-sectional study.Acta diabetologica · 2025Article
- Insomnia Phenotypes, Cardiovascular Risk and Their Link to Brain Health.Circulation research · 2025Review
- Exploration of common pathogenic genes between cerebral amyloid angiopathy and insomnia based on bioinformatics and experimental validation.Scientific reports · 2025Article
- Plain Language Summary: Lifestyle Interventions for Treatment and Remission of Type 2 Diabetes and Prediabetes in Adults.American journal of lifestyle medicine · 2025Article
- Sleep habits in the pathogenesis and management of diabesity.Journal of diabetes investigation · 2025Review
- Lifestyle Interventions for Treatment and Remission of Type 2 Diabetes and Prediabetes in Adults: A Clinical Practice Guideline From the American College of Lifestyle Medicine.American journal of lifestyle medicine · 2025Article
- The triangulation of multimorbidity: A systematic review of primary sleep disorders, hypertension, and psychiatric disorders.PLOS global public health · 2025Article
- Concentrated micro choice-based treatment for type 2 diabetes is associated with decreased risk of sleep apnoea, less daytime sleepiness and lower insomnia symptoms. A non-randomized pre - post pilot study.Frontiers in sleep · 2025Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe aimed to determine the prevalence of insomnia and insomnia symptoms and its association with metabolic parameters and glycemic control in people with type 2 diabetes (T2D) in a systematic review and meta-analysis. DATA SOURCES: A systematic literature search was conducted in PubMed/Embase until March 2018. STUDY SELECTION: Included studies described prevalence of insomnia or insomnia symptoms and/or its association with metabolic parameters or glycemic control in adults with T2D. DATA EXTRACTION: Data extraction was performed independently by 2 reviewers, on a standardized, prepiloted form. An adaptation of Quality Assessment Tool for Quantitative Studies was used to assess the methodological quality of the included studies. DATA SYNTHESIS: When possible, results were meta-analyzed using random-effects analysis and rated using Grading of Recommendations Assessment, Development and Evaluation (GRADE).
resultsA total of 11 329 titles/abstracts were screened and 224 were read full text in duplicate, of which 78 studies were included. The pooled prevalence of insomnia (symptoms) in people with T2D was 39% (95% confidence interval, 34-44) with I2 statistic of 100% (P < 0.00001), with a very low GRADE of evidence. Sensitivity analyses identified no clear sources of heterogeneity. Meta-analyses showed that in people with T2D, insomnia (symptoms) were associated with higher hemoglobin A1c levels (mean difference, 0.23% [0.1-0.4]) and higher fasting glucose levels (mean difference, 0.40 mmol/L [0.2-0.7]), with a low GRADE of evidence. The relative low methodological quality and high heterogeneity of the studies included in this meta-analysis complicate the interpretation of our results.
conclusionsThe prevalence of insomnia (symptoms) is 39% (95% confidence interval, 34-44) in the T2D population and may be associated with deleterious glycemic control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.