ArticleeLife2019
Brain-specific Drp1 regulates postsynaptic endocytosis and dendrite formation independently of mitochondrial division.
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In one paragraph
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
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Who cites it
27 citing papers in PubMed, 47 citations in OpenAlex.
- Hippocampal CA1 and CA2 dendritic compartment-specific differences in mitochondrial form and function.Progress in neurobiology · 2026Article
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- Hippocampal cell- and circuit-specific differences in mitochondrial form and function.bioRxiv : the preprint server for biology · 2025Article
- AGPAT2 acts at the crossroads of lipid biosynthesis and DRP1-mediated ER morphogenesis.Nature communications · 2025Article
- Ultrastructural membrane dynamics of mouse and human cortical synapses.bioRxiv : the preprint server for biology · 2025Article
- Mitochondrial fission - changing perspectives for future progress.Journal of cell science · 2025Review
- Article
- Decoding brain aging trajectory: predictive discrepancies, genetic susceptibilities, and emerging therapeutic strategies.Frontiers in aging neuroscience · 2025Review
- Early Handling Exerts Anxiolytic Effects and Alters Brain Mitochondrial Dynamics in Adult High Anxiety Mice.Molecular neurobiology · 2024Article
- Kainate-Induced Reorganization the Dentate Gyrus of the Hippocampus Is Accompanied by Activation of Mitochondrial Fission in the Granular Layer Neurons.Bulletin of experimental biology and medicine · 2024Article
- Dynamin 1xA interacts with Endophilin A1 via its spliced long C-terminus for ultrafast endocytosis.The EMBO journal · 2024Article
- Targeting Mitochondrial Dysfunction and Reactive Oxygen Species for Neurodegenerative Disease Treatment.International journal of molecular sciences · 2024Review
- Systemic phospho-defective and phospho-mimetic Drp1 mice exhibit normal growth and development with altered anxiety-like behavior.iScience · 2024Article
- Activity-dependent compartmentalization of dendritic mitochondria morphology through local regulation of fusion-fission balance in neurons in vivo.Nature communications · 2024Article
- The Contribution of Hippocampal All-Trans Retinoic Acid (ATRA) Deficiency to Alzheimer's Disease: A Narrative Overview of ATRA-Dependent Gene Expression in Post-Mortem Hippocampal Tissue.Antioxidants (Basel, Switzerland) · 2023Review
- Targeting an allosteric site in dynamin-related protein 1 to inhibit Fis1-mediated mitochondrial dysfunction.Nature communications · 2023Article
- Mitochondrial morphology controls fatty acid utilization by changing CPT1 sensitivity to malonyl-CoA.The EMBO journal · 2023Article
- Amyloid-β accumulation in human astrocytes induces mitochondrial disruption and changed energy metabolism.Journal of neuroinflammation · 2023Article
- Article
- Defunctionalizing intracellular organelles such as mitochondria and peroxisomes with engineered phospholipase A/acyltransferases.Nature communications · 2022Article
Corrections and comments
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Authors and funding
15 authors at 1 institution in 1 country.
Kie ItohDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, United States.ORCID 0000-0003-4379-400X
Daisuke MurataDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, United States.
Takashi KatoDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, United States.
Tatsuya YamadaDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, United States.
Yoichi ArakiSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, United States.
Atsushi SaitoDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, United States.
Yoshihiro AdachiDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, United States.
Atsushi IgarashiDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, United States.
Shuo LiDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, United States.
Mikhail PletnikovSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, United States.
Richard L HuganirSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, United States.
Shigeki WatanabeDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, United States.
Atsushi KamiyaDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, United States.
Miho IijimaDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, United States.
Hiromi SesakiDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, United States.ORCID 0000-0002-6877-3929
Johns Hopkins University · US
Funding
Project 3P50MH094268 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SAWA, AKIRA · 2011 to 2020
$19.9MMutant DISC 1 and Abnormal Neurodevelopment in Mental IllnessR01MH083728 · NIMH · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI PLETNIKOV, MIKHAIL V · 2009 to 2020
$4.9MRegulation of Intracellular SignalingR35GM131768 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Miho Iijima · 2019 to 2026
$4.0MMolecular mechanism of astrocytic vulnerability to adolescent cannabis useR01DA041208 · NIDA · JOHNS HOPKINS UNIVERSITY · PI KAMIYA, ATSUSHI, PLETNIKOV, MIKHAIL V · 2016 to 2020
$2.9MLipid Signaling in ChemotaxisR01GM084015 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI IIJIMA, MIHO · 2009 to 2019
$2.9MMitochondrial Quality Control by Drp1R01GM123266 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI SESAKI, HIROMI · 2018 to 2021
$1.4MRegulation of Mitochondrial Division by Phosphatidic AcidR01GM130695 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI SESAKI, HIROMI · 2019 to 2021
$933kNIDA NIH HHS DA041208NIDA NIH HHS R01 DA041208NIGMS NIH HHS GM123266NIGMS NIH HHS GM130695NIGMS NIH HHS GM131768NIGMS NIH HHS R01 GM084015NIGMS NIH HHS R01 GM123266NIGMS NIH HHS R01 GM130695NIGMS NIH HHS R35 GM131768NIMH NIH HHS MH083728NIMH NIH HHS P50 MH094268NIMH NIH HHS R01 MH083728
Abstract
Dynamin-related protein 1 (Drp1) divides mitochondria as a mechano-chemical GTPase. However, the function of Drp1 beyond mitochondrial division is largely unknown. Multiple Drp1 isoforms are produced through mRNA splicing. One such isoform, Drp1
Indexed as
EndocytosisMitochondrial DynamicsAnimalsBrainDendritesDynaminsMiceMice, KnockoutProtein IsoformsSynapsesDnm1l protein, mouseDynaminsProtein Isoformsbraincell biologyDrp1endocytosismitochondriamouse
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.