Natural Tr1-like cells do not confer long-term tolerogenic memory.
Koshika Yadava, Carlos Obed Medina, Heather Ishak, Irina Gurevich, Hedwich Kuipers, Elya Ali Shamskhou, Ievgen O Koliesnik, James J Moon, Casey Weaver, Kari Christine Nadeau and 1 more
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
11 authors at 5 institutions in 3 countries.
Koshika Yadava *Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Beckman Center, Stanford University School of Medicine, Stanford, United States.ORCID 0000-0002-5827-9177
Carlos Obed Medina *Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Beckman Center, Stanford University School of Medicine, Stanford, United States.ORCID 0000-0002-8324-7994
Heather IshakDivision of Infectious Diseases and Geographic Medicine, Department of Medicine, Beckman Center, Stanford University School of Medicine, Stanford, United States.
Irina GurevichDivision of Infectious Diseases and Geographic Medicine, Department of Medicine, Beckman Center, Stanford University School of Medicine, Stanford, United States.
Hedwich KuipersDivision of Infectious Diseases and Geographic Medicine, Department of Medicine, Beckman Center, Stanford University School of Medicine, Stanford, United States.
Elya Ali ShamskhouDivision of Infectious Diseases and Geographic Medicine, Department of Medicine, Beckman Center, Stanford University School of Medicine, Stanford, United States.
Ievgen O KoliesnikDivision of Infectious Diseases and Geographic Medicine, Department of Medicine, Beckman Center, Stanford University School of Medicine, Stanford, United States.
James J MoonCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Charlestown, United States.ORCID 0000-0001-8246-931X
Casey WeaverBevill Biomedical Research Building, The University of Alabama at Birmingham, Birmingham, United States.
Kari Christine NadeauSean N Parker Center for Allergy & Asthma Research, Stanford University, Mountain View, United States.
Paul L BollykyDivision of Infectious Diseases and Geographic Medicine, Department of Medicine, Beckman Center, Stanford University School of Medicine, Stanford, United States.ORCID 0000-0003-2499-9448
Stanford University · USHarvard University · USUniversity of Alabama at Birmingham · USUniversity of Calgary · CAUniversity of Oxford · GB
Funding
Stanford Center for Clinical & Translational Education and Research (Spectrum)UL1TR003142 · NCATS · STANFORD UNIVERSITY · PI O'HARA, RUTH M · 2019 to 2023
$45.0M
Spectrum Stanford Center for clinical and Translational Research and EducationUL1TR001085 · NCATS · STANFORD UNIVERSITY · PI CULLEN, MARK RICHARD, GREENBERG, HARRY BERNARD · 2013 to 2017
$37.1M
Tetramer CoreU19AI095261 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI VON ANDRIAN, ULRICH H · 2011 to 2015
$10.8M
Tissue Cytokine Sequestration and Immune Regulation in AutoimmunityU01AI101984 · NIAID · STANFORD UNIVERSITY · PI BOLLYKY, PAUL L · 2012 to 2021
$5.0M
Lymph Node Extracellular Matrix in Antigen Presentation and Immune RegulationR01DK096087 · NIDDK · STANFORD UNIVERSITY · PI BOLLYKY, PAUL L · 2012 to 2021
$3.4M
ECM Costimulation of Immunoregulatory Pathways in Airway InflammationR01HL113294 · NHLBI · STANFORD UNIVERSITY · PI BOLLYKY, PAUL L · 2012 to 2016
$2.0M
The Development of 4-methylumbelliferone Pro-drugs to Prevent Autoimmune DiabetesR01DK114174 · NIDDK · STANFORD UNIVERSITY · PI BOLLYKY, PAUL L · 2018 to 2020
$1.3M
Heparanase and Regulatory T cell Stability and FunctionR21AI133240 · NIAID · STANFORD UNIVERSITY · PI BOLLYKY, PAUL L · 2018 to 2019
$438k
NCATS NIH HHS UL1 TR001085NCATS NIH HHS UL1 TR003142NHLBI NIH HHS R01 HL113294NIAID NIH HHS R21 AI133240NIAID NIH HHS U01 AI101984NIAID NIH HHS U19 AI095261NIDDK NIH HHS R01 DK096087NIDDK NIH HHS R01 DK114174NIH HHS R01 DK096087-01NIH HHS R01 HL113294-01A1NIH HHS U01 AI101984Stanford University Diversifying Academia, Recruiting ExcellenceStanford University Molecular and Cellular Immunobiology Training Grant 5 T32 AI07920Swiss National Science Foundation Early postdoctoral mobility grant
6 · The paper itself
Abstract
IL-10-producing Tr1 cells promote tolerance but their contributions to tolerogenic memory are unclear. Using 10BiT mice that carry a Foxp3-eGFP reporter and stably express CD90.1 following IL-10 production, we characterized the spatiotemporal dynamics of Tr1 cells in a house dust mite model of allergic airway inflammation. CD90.1+Foxp3-IL-10+ Tr1 cells arise from memory cells and rejoin the tissue-resident memory T-cell pool after cessation of IL-10 production. Persistent antigenic stimulation is necessary to sustain IL-10 production and
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Natural Tr1-like cells do not confer long-term tolerogenic memory. · full record | OpenQuestion