Evidence map›Paper›PMID 31603288›Full record

ReviewAdvanced healthcare materials2020

Fiber Scaffold Patterning for Mending Hearts: 3D Organization Bringing the Next Step.

Marleen Kristen, Madison J Ainsworth, Nino Chirico, Casper F T van der Ven, Pieter A Doevendans, Joost P G Sluijter, Jos Malda, Alain van Mil, Miguel Castilho

Abstract readReview
In one paragraph

Review in Advanced healthcare materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Small Diameter Vascular Grafts Made in Minutes.Advanced materials (Deerfield Beach, Fla.) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marleen KristenRegenerative Medicine Center, University Medical Center Utrecht, Utrecht, 3584 CT, The Netherlands.
Madison J AinsworthRegenerative Medicine Center, University Medical Center Utrecht, Utrecht, 3584 CT, The Netherlands.
Nino ChiricoRegenerative Medicine Center, University Medical Center Utrecht, Utrecht, 3584 CT, The Netherlands.
Casper F T van der VenRegenerative Medicine Center, University Medical Center Utrecht, Utrecht, 3584 CT, The Netherlands.
Pieter A DoevendansDepartment of Cardiology, Experimental Cardiology Laboratory, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands.
Joost P G SluijterRegenerative Medicine Center, University Medical Center Utrecht, Utrecht, 3584 CT, The Netherlands.
Jos MaldaRegenerative Medicine Center, University Medical Center Utrecht, Utrecht, 3584 CT, The Netherlands.ORCID 0000-0002-9241-7676
Alain van MilRegenerative Medicine Center, University Medical Center Utrecht, Utrecht, 3584 CT, The Netherlands.
Miguel CastilhoRegenerative Medicine Center, University Medical Center Utrecht, Utrecht, 3584 CT, The Netherlands.

Funding

European Research Council 647426European Research Council 725229Gravitation ProgramH2020 European Research Council 647426H2020 European Research Council 725229Marie Skłodowska-Curie Actions 801540Netherlands Organization for Scientific Research 024.003.013ReumaNederland LLP-12University Medical Center Utrecht-Technical University Eindhoven
6 · The paper itself

Abstract

Heart failure (HF) is a leading cause of death worldwide. The most common conditions that lead to HF are coronary artery disease, myocardial infarction, valve disorders, high blood pressure, and cardiomyopathy. Due to the limited regenerative capacity of the heart, the only curative therapy currently available is heart transplantation. Therefore, there is a great need for the development of novel regenerative strategies to repair the injured myocardium, replace damaged valves, and treat occluded coronary arteries. Recent advances in manufacturing technologies have resulted in the precise fabrication of 3D fiber scaffolds with high architectural control that can support and guide new tissue growth, opening exciting new avenues for repair of the human heart. This review discusses the recent advancements in the novel research field of fiber patterning manufacturing technologies for cardiac tissue engineering (cTE) and to what extent these technologies could meet the requirements of the highly organized and structured cardiac tissues. Additionally, future directions of these novel fiber patterning technologies, designs, and applicability to advance cTE are presented.

Indexed as

Tissue EngineeringAnimalsBiocompatible MaterialsExtracellular MatrixHeart FailureHumansHydrogelsMyocardiumPrinting, Three-DimensionalTissue ScaffoldsBiocompatible MaterialsHydrogelscardiac regenerationcardiac tissue engineeringextracellular matricesfiber manufacturing technologiesfiber scaffoldsinstructive biomaterials

Identifiers

PMID31603288
PMCPMC7116178

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.