ArticleAnnals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc2020
The clinical significance of premature atrial contractions: How frequent should they become predictive of new-onset atrial fibrillation.
Article in Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Heart Rate Variability Nomogram Predicts Atrial Fibrillation in Patients with Moderate to High Burden of Premature Ventricular Complexes.Medicina (Kaunas, Lithuania) · 2026Article
- Efficacy evaluation of Wenxin Keli in treating anthracycline-induced atrial arrhythmias (WARMA study): protocol for a multicenter, randomized, double-blind, placebo-controlled clinical trial.Frontiers in cardiovascular medicine · 2026Article
- Nonsustained Atrial Fibrillation in Ambulatory ECG Recording and Thromboembolic Events in Long term Follow-Up.Anatolian journal of cardiology · 2025Article
- Blocked Atrial Bigeminy as an Unusual Cause of Bradycardia: A Case Report.International medical case reports journal · 2025Article
- Left atrial anomalous bands associated with arrhythmia detected by computed tomography during coronary CT angiography: a case series.American journal of translational research · 2025Article
- Atrial arrhythmia in adults with sickle cell anemia: a missing link toward understanding and preventing strokes.Blood advances · 2024Article
- Supervised Machine Learning to Examine Factors Associated with Respiratory Sinus Arrhythmias and Ectopic Heart Beats in Adults: A Pilot Study.Hearts (Basel, Switzerland) · 2024Article
- Risk factors for enhanced recovery after surgery failure in patients undergoing lung cancer resection with concomitant cardiovascular disease: A single-center retrospective study.Asia-Pacific journal of oncology nursing · 2024Article
- Risk Factors Associated With Atrial Fibrillation in Elderly Patients.Journal of clinical medicine research · 2023Article
- Assessment of atrial conduction times in patients with frequent premature ventricular complex.Journal of arrhythmia · 2023Article
- Excessive Supraventricular Ectopic Activity and the Risk of Atrial Fibrillation and Stroke: A Systematic Review and Meta-Analysis.Journal of cardiovascular development and disease · 2022Review
- A case of successful catheter ablation of blocked atrial bigeminy and bradycardia with the recovery of normal sinus rhythm and myocardial reverse remodeling.Clinical case reports · 2022Article
- Development and Validation of an Algorithm for the Digitization of ECG Paper Images.Sensors (Basel, Switzerland) · 2022Article
- Photoplethysmography-Based Machine Learning Approaches for Atrial Fibrillation Prediction: A Report From the Huawei Heart Study.JACC. Asia · 2021Article
- Association of Longitudinal Changes in Cardiac Biomarkers With Atrial and Ventricular Arrhythmias (from the Atherosclerosis Risk in Communities [ARIC] Study).The American journal of cardiology · 2021Article
- The clinical significance of premature atrial contractions: How frequent should they become predictive of new-onset atrial fibrillation.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2020Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough previous studies reported frequent premature atrial contractions(fPACs) increased the risk of adverse cardiovascular outcomes, especially atrial fibrillation(AF), there is a substantial inconsistency between reports concerning the definition of fPAC. In this study, we aimed to investigate the relationship between fPAC and cardiovascular outcomes, especially AF. We further searched for a cutoff value of fPAC for prediction of AF.
methodsWe retrospectively analyzed the ambulatory 24-hr Holter monitoring records and 392 patients included. Frequent PAC was defined as more than 720 PAC/24 hr as used for frequent ventricular premature beats. Patients' baseline characteristics, echocardiographic variables and medical history were recorded.
resultsThere were 189 patients with fPAC and 203 patients without fPAC. Patients with fPAC had more comorbidities in terms of hypertension, diabetes mellitus, coronary artery disease and congestive heart failure. CHA2DS2-VaSc was higher in patients with fPAC. Mean follow-up duration was 31 months, and the number of patients with new-onset AF during follow-up was significantly higher in fPAC group (22% vs. 5%, p < .001). fPAC was significantly and independently associated with new-onset AF and predicted AF with a cutoff value of 3,459 PAC/24 hr, and the risk of AF was 11-fold higher than those with <3,000 PAC/24 hr. In addition, an increased CHA2DS2-VaSc score was also associated with new-onset atrial fibrillation.
conclusionIn our study, we have demonstrated that fPAC is significantly associated with new-onset AF, and this association is the strongest among those patients who have more than 3,000 PAC in 24 hr.
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