ArticleSchizophrenia bulletin2020
Toward a Neural Model of the Openness-Psychoticism Dimension: Functional Connectivity in the Default and Frontoparietal Control Networks.
Article in Schizophrenia bulletin, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- The hierarchical taxonomy of psychopathology and the search for neurobiological substrates of mental illness: A systematic review and roadmap for future research.Journal of psychopathology and clinical science · 2024Pooled it
- Functional differentiation of the default and frontoparietal control networks predicts individual differences in creative achievement: evidence from macroscale cortical gradients.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Fronto-Thalamic Structural Connectivity Associated With Schizotypy, a Psychosis Risk Phenotype, in Nonclinical Subjects.Schizophrenia bulletin · 2025Article
- Characterizing the relationship between personality dimensions and psychosis-specific clinical characteristics.Schizophrenia research · 2025Article
- Article
- Exploring the profile and risk factors associated with self-harm ideation and behaviors in adolescents with high psychoticism.Frontiers in psychiatry · 2025Article
- Psychosis superspectrum II: neurobiology, treatment, and implications.Molecular psychiatry · 2024Review
- Meta-Analytic Review of Temperamental Correlates of the Five-Factor Model and Hierarchical Taxonomy of Psychopathology Domains.Indian journal of psychological medicine · 2024Review
- Conceptualizing a less paranoid schizophrenia.Philosophy, ethics, and humanities in medicine : PEHM · 2023Review
- Covariation of preadult environmental exposures, adult brain imaging phenotypes, and adult personality traits.Molecular psychiatry · 2023Article
- Resting-State Functional Connectivity Explained Psychotic-like Experiences in the General Population and Partially Generalized to Patients and Relatives.Biological psychiatry global open science · 2023Article
- Neurobehavioral indices of gaze perception are associated with social cognition across schizophrenia patients and healthy controls.Journal of psychopathology and clinical science · 2023Article
- Pedunculopontine-induced cortical decoupling as the neurophysiological locus of dissociation.Psychological review · 2023Article
- Activation of the default network during a theory of mind task predicts individual differences in agreeableness and social cognitive ability.Cognitive, affective & behavioral neuroscience · 2022Article
- The cognitive basis of psychosocial impact in COVID-19 pandemic. Does it encircle the default mode network of the brain? A pragmatic proposal.Medical research archives · 2022Article
- Integration of structural brain networks is related to openness to experience: A diffusion MRI study with CSD-based tractography.Frontiers in neuroscience · 2022Article
- Impact of Independent Component Analysis Dimensionality on the Test-Retest Reliability of Resting-State Functional Connectivity.Brain connectivity · 2021Article
- Default mode network functional connectivity negatively associated with trait openness to experience.Social cognitive and affective neuroscience · 2021Article
- Extraversion but not depression predicts reward sensitivity: Revisiting the measurement of anhedonic phenotypes.Journal of personality and social psychology · 2021Article
- From Description to Explanation: Integrating Across Multiple Levels of Analysis to Inform Neuroscientific Accounts of Dimensional Personality Pathology.Journal of personality disorders · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Psychosis proneness has been linked to heightened Openness to Experience and to cognitive deficits. Openness and psychotic disorders are associated with the default and frontoparietal networks, and the latter network is also robustly associated with intelligence. We tested the hypothesis that functional connectivity of the default and frontoparietal networks is a neural correlate of the openness-psychoticism dimension. Participants in the Human Connectome Project (N = 1003) completed measures of psychoticism, openness, and intelligence. Resting state functional magnetic resonance imaging was used to identify intrinsic connectivity networks. Structural equation modeling revealed relations among personality, intelligence, and network coherence. Psychoticism, openness, and especially their shared variance were related positively to default network coherence and negatively to frontoparietal coherence. These associations remained after controlling for intelligence. Intelligence was positively related to frontoparietal coherence. Research suggests that psychoticism and openness are linked in part through their association with connectivity in networks involving experiential simulation and cognitive control. We propose a model of psychosis risk that highlights roles of the default and frontoparietal networks. Findings echo research on functional connectivity in psychosis patients, suggesting shared mechanisms across the personality-psychopathology continuum.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.