Evidence map›Paper›PMID 31602966›Full record

Trial reportKorean journal of anesthesiology2020

Efficacy of trospium for prevention of catheter-related bladder discomfort: a prospective, randomized, placebo-controlled, double-blind study.

Vinit Kumar Srivastava, Sanjay Agrawal, Sweta Anil Deshmukh, Febin Noushad, Saima Khan, Raj Kumar

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Korean journal of anesthesiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Vinit Kumar SrivastavaDepartment of Anesthesiology, Apollo Hospitals Bilaspur, Chhattisgarh, India.
Sanjay AgrawalDepartment of Anesthesiology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Sweta Anil DeshmukhDepartment of Anesthesiology, Apollo Hospitals Bilaspur, Chhattisgarh, India.
Febin NoushadDepartment of Anesthesiology, Apollo Hospitals Bilaspur, Chhattisgarh, India.
Saima KhanDepartment of Anesthesiology, Apollo Hospitals Bilaspur, Chhattisgarh, India.
Raj KumarDepartment of Neurosurgery, Apollo Hospitals Bilaspur, Chhattisgarh, India.
Apollo Hospitals · INAll India Institute of Medical Sciences Rishikesh · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCatheter-related bladder discomfort (CRBD) is a frequent complaint after awakening from anesthesia in patients receiving perioperative bladder catheterization. Overactive bladder (OAB) and CRBD show similar symptoms; thus, drugs used for the management of OAB influence symptoms of CRBD. Trospium chloride has been found effective in managing resistant cases of OAB. We evaluated the efficacy of oral trospium on CRBD in the postoperative period.

methodsSixty-four male and female adult patients, with planned spinal surgery and requiring urinary bladder catheterization, were randomly divided into two groups of 32 each. Group T patients received 60 mg extended-release oral trospium (extended-release) 1 h before induction of anesthesia and Group C patients received a similar-looking placebo. The anesthetic technique was identical in both groups. The CRBD score was evaluated in the postoperative ward using a 4-point scale (1 = no discomfort, 2 = mild, 3 = moderate, 4 = severe). Readings were recorded on arrival (0 h), and 1 h, 2 h, and 6 h postoperatively. All patients received fentanyl for postoperative pain relief.

resultsThe incidence of CRBD was significantly higher in group C than in group T at 0 h (66% vs 22%, P=0.001) and 1 h postoperatively (72% vs 28%, P=0.001). The incidence of moderate to severe CRBD was higher in group C at postoperative 2 h (82% vs 14%, P=0.004). There was no significant difference in postoperative fentanyl requirements.

conclusionsPretreatment with 60 mg ER trospium reduced the incidence and severity of CRBD in the early postoperative period.

Indexed as

AdultBenzilatesDouble-Blind MethodFemaleHumansMaleMiddle AgedNortropanesPreoperative CareProspective StudiesTreatment OutcomeUrinary BladderUrinary CatheterizationUrinary CathetersUrological AgentsBenzilatesNortropanestrospium chlorideUrological AgentsAntimuscarinic agentsMuscarinic receptorsOveractive bladderPostoperative periodTrospiumUrinary catheterization

Identifiers

PMID31602966
PMCPMC7113168
OpenAlexW2980168068

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.