Observational studyCongenital heart disease2019
Exercise responses in children and adults with a Fontan circulation at simulated altitude.
Observational study in Congenital heart disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Cardiopulmonary exercise response at high altitude in patients with congenital heart disease: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2024Pooled it
- EACTS Expert Consensus Document on Civil Aviation Following Cardiothoracic Surgery and Transcatheter Procedures.Interdisciplinary cardiovascular and thoracic surgery · 2026Review
- Mountains and Waves: Fontan Circulation in Different Environmental Conditions.Pediatric cardiology · 2025Review
- Fitness to fly for children and adolescents after Fontan palliation.Frontiers in cardiovascular medicine · 2023Article
- Influence of 24 h Simulated Altitude on Red Blood Cell Deformability and Hematological Parameters in Patients with Fontan Circulation.Metabolites · 2022Article
- Adequate exercise response at artificial altitude in Fontan patients.Frontiers in pediatrics · 2022Article
- Systemic ventricular function in Fontan patients at rest and after exercise at altitude.Frontiers in pediatrics · 2022Article
- Predictors of Poor Functional Status in Adult Fontan Patients Living at Moderate Altitude.Pediatric cardiology · 2021Article
- Physiological Responses at Rest and Exercise to High Altitude in Lowland Children and Adolescents.Life (Basel, Switzerland) · 2021Article
- Altitude exposure in pediatric pulmonary hypertension-are we ready for (flight) recommendations?Cardiovascular diagnosis and therapy · 2021Review
- Exercise responses in children and adults with a Fontan circulation at simulated altitude.Congenital heart disease · 2019Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTraveling to high altitude has become more popular. High-altitude exposure causes hypobaric hypoxia. Exposure to acute high altitude, during air travel or mountain stays, seems to be safe for most patients with congenital heart disorders (CHD). Still, current guidelines for CHD patients express concerns regarding safety of altitude exposure for patients with a Fontan circulation. Therefore, investigating hemodynamic and pulmonary responses of acute high-altitude exposure (±2500 m) at rest and during maximal exercise in patients with Fontan circulation can provide clarity in this dispute and may contribute to improvement of clinical counseling.
methodsTwenty-one Fontan patients with 21 age-matched healthy controls, aged 8-40 years, were enrolled in an observational study. Participants performed two cardiopulmonary exercise tests on a cycle ergometer with breath-by-breath respiratory gas analyses combined with noninvasive impedance cardiac output measurements: one at sea level (±6 m) and one at simulated high altitude (±2500 m), respectively.
resultsThe effect of altitude exposure was different in rest for saturation (-2.3% vs -4.1%) between Fontan patients and healthy controls (P < .05). At peak exercise the effects of high altitude exposure was different on VO
conclusionAlthough, acute high-altitude exposure has a detrimental effect on exercise capacity, the impact on pulmonary and hemodynamic responses of high-altitude exposure is comparable between Fontan patients and healthy controls.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.