Evidence map›Paper›PMID 31602595›Full record

ArticleEuropean journal of drug metabolism and pharmacokinetics2020

Excretion, Metabolism and Cytochrome P450 Inhibition of Methyl 3,4-Dihydroxybenzoate (MDHB): A Potential Candidate to Treat Neurodegenerative Diseases.

Jia Hui Wang, Ke Qi Chen, Jun Xing Jiang, Huan Yong Li, Jun Ping Pan, Ji Yan Su, Lin Wang, Yang Hu, Xiang Nan Mi, Yi Rong Xin and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in European journal of drug metabolism and pharmacokinetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Jia Hui WangDepartment of Pharmacology, College of Basic Medicine, Jinan University, Guangzhou, China.
Ke Qi ChenDepartment of Pharmacology, College of Basic Medicine, Jinan University, Guangzhou, China.
Jun Xing JiangDepartment of Pharmacology, College of Basic Medicine, Jinan University, Guangzhou, China.
Huan Yong LiAnalytical and Testing Center, Jinan University, Guangzhou, China.
Jun Ping PanDepartment of Pharmacology, College of Basic Medicine, Jinan University, Guangzhou, China.
Ji Yan SuState Key Laboratory of Applied Microbiology Southern China, Guangdong Institute of Microbiology, Guangzhou, China.
Lin WangAnalytical and Testing Center, Jinan University, Guangzhou, China.
Yang HuDepartment of Pharmacology, College of Basic Medicine, Jinan University, Guangzhou, China.
Xiang Nan MiDepartment of Pharmacology, College of Basic Medicine, Jinan University, Guangzhou, China.
Yi Rong XinDepartment of Pharmacology, College of Basic Medicine, Jinan University, Guangzhou, China.
Qin GaoDepartment of Pharmacology, College of Basic Medicine, Jinan University, Guangzhou, China.
Xiang Long ZhaoSCIEX (China) Co., Ltd., Guangzhou, China.
Fei XiaoDepartment of Pharmacology, College of Basic Medicine, Jinan University, Guangzhou, China. xiaofei@jnu.edu.cn.
Huan Min LuoDepartment of Pharmacology, College of Basic Medicine, Jinan University, Guangzhou, China. tlhm@jnu.edu.cn.ORCID http://orcid.org/0000-0002-7969-9672
Jinan University · CNInstitute of Microbiology · CNSun Yat-sen University · CN

Funding

China's 111 project B14036National Natural Science Foundation of China 81473296
6 · The paper itself

Abstract

BACKGROUND AND

objectivesMethyl 3,4-dihydroxybenzoate (MDHB) has the potential to prevent neurodegenerative diseases (NDDs). The present work investigated its excretion, metabolism, and cytochrome P450-based drug-drug interactions (DDIs).

methodsAfter intragastric administration of MDHB, the parent drug was assayed in the urine and faeces of mice. Metabolites of MDHB in the urine, faeces, brain, plasma and liver were detected by liquid chromatography-hybrid quadrupole time-of-flight mass spectrometry (LC-QTOF/MS). A cocktail approach was used to evaluate the inhibition of cytochrome P450 isoforms by MDHB.

resultsThe cumulative excretion permille of MDHB in the urine and faeces were found to be 0.67 ± 0.31 and 0.49 ± 0.44‰, respectively. A total of 96 metabolites of MDHB were identified, and all IC

conclusionsThe results suggest that MDHB has a low parent drug cumulative excretion percentage and that MDHB has multiple metabolites and is mainly metabolized through the loss of -CH

Indexed as

AnimalsCytochrome P-450 Enzyme SystemDrug InteractionsFecesHydroxybenzoatesMaleMiceMolecular StructureNeurodegenerative DiseasesNeuroprotective AgentsProtein IsoformsRenal EliminationCytochrome P-450 Enzyme SystemHydroxybenzoatesmethyl 3,4-dihydroxybenzoateNeuroprotective AgentsProtein Isoforms

Identifiers

PMID31602595
OpenAlexW2979797850

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.