ArticleMolecular biology reports2019
Upregulation of secreted aspartyl proteinase genes of fluconazole-sensitive Candida albicans isolates.
Article in Molecular biology reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- 2,4-Diacetylphloroglucinol ModulatesJournal of fungi (Basel, Switzerland) · 2022Article
- The effects of secreted aspartyl proteinase inhibitor ritonavir on azoles-resistant strains of Candida albicans as well as regulatory role of SAP2 and ERG11.Immunity, inflammation and disease · 2021Article
- An Integrated Analysis of Intracellular Metabolites and Virulence Gene Expression during Biofilm Development of a Clinical Isolate ofInternational journal of molecular sciences · 2021Article
- Metabolic profiling of Candida clinical isolates of different species and infection sources.Scientific reports · 2020Article
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Authors and funding
3 authors.
Funding
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Abstract
Candida albicans infection development depends on several factors associated with this etiological agent, including secreted aspartyl protease (Sap) production. Sap expression commonly occurs under selective pressure caused by the presence of antifungals. Fluconazole is the main antifungal drug used for treatment or prophylaxis. This study investigated the influence of inhibitory and sub-inhibitory fluconazole concentrations on Sap activity and their gene transcription for three clinical C. albicans isolates. Two isolates presented significant increases in Sap activity and transcription of SAP 1-8 genes in the presence of 1 MIC
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