Evidence map›Paper›PMID 31602565›Full record

ArticleMolecular diversity2020

Estrone derived 2-naphthol analogue in the diastereoselective one-pot Betti-condensation.

Irena Zagranyarska, Kalina Kostova, Yulian Zagranyarski, Rositsa Nikolova, Boris Shivachev, Vladimir Dimitrov

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Article in Molecular diversity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Irena ZagranyarskaInstitute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev 9, 1113, Sofia, Bulgaria.
Kalina KostovaInstitute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev 9, 1113, Sofia, Bulgaria.
Yulian ZagranyarskiFaculty of Chemistry and Pharmacy, Sofia University "St. Kliment Ohridski", 1 James Bourchier Blvd., 1164, Sofia, Bulgaria.
Rositsa NikolovaInstitute of Mineralogy and Crystallography "Acad. Ivan Kostov", Bulgarian Academy of Sciences, Acad. G. Bonchev 107, 1113, Sofia, Bulgaria.
Boris ShivachevInstitute of Mineralogy and Crystallography "Acad. Ivan Kostov", Bulgarian Academy of Sciences, Acad. G. Bonchev 107, 1113, Sofia, Bulgaria.
Vladimir DimitrovInstitute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev 9, 1113, Sofia, Bulgaria. vdim@orgchm.bas.bg.ORCID http://orcid.org/0000-0002-9668-9388

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The utility of deoxy-isoequilenine synthesized from estrone as valuable 2-naphthol analogue is demonstrated in the three components Betti-condensation. A simple, efficient and green procedure for the synthesis of aminobenzylnaphthol analogues (so-called Betti bases) has been realized highly diastereoselectively by using (S)-phenylethylamine and 1- or 2-naphthaldehyde. The absolute configuration of the new chiral compounds obtained has been determined by means of NMR experiments and confirmed by X-ray crystallography. The chiral steroidal aminobenzylnaphthols have been evaluated as pre-catalysts for the addition of diethylzinc to aldehydes with enantioselectivities of up to 98% ee.

Indexed as

AldehydesCatalysisCrystallography, X-RayEstroneNaphthalenesNaphtholsOrganometallic CompoundsPhenethylaminesStereoisomerism2-naphthaldehyde2-naphtholAldehydesdiethylzincEstroneNaphthalenesNaphtholsOrganometallic CompoundsPhenethylaminesAbsolute configurationBetti-condensationChiral ligandsDeoxy-isoequilenineDiethylzinc addition

Identifiers

PMID31602565

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.