ArticleAnnals of intensive care2019
Evaluation of least significant changes of pulse contour analysis-derived parameters.
Article in Annals of intensive care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04934943 ("Mini Fluid Challenge Assessment), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
"Mini Fluid Challenge Assessment: a Comparison Among Three Hemodynamic Tools"
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Changes in pulse pressure variation induced by passive leg raising test to predict preload responsiveness in mechanically ventilated patients with low tidal volume in ICU: a systematic review and meta-analysis.Critical care (London, England) · 2025Pooled it
- Assessing fluid responsiveness in mechanically ventilated patients with intra-abdominal hypertension: a two-center, prospective, observational study.Critical care (London, England) · 2026Observational
- Trendelenburg position is a reasonable alternative to passive leg raising for predicting volume responsiveness in mechanically ventilated patients in the ICU.Critical care (London, England) · 2025Article
- Testing preload responsiveness by the tidal volume challenge assessed by the photoplethysmographic perfusion index.Critical care (London, England) · 2024Article
- Bias, trending ability and diagnostic performance of a non-calibrated multi-beat analysis continuous cardiac output monitor to identify fluid responsiveness in critically ill patients.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2024Article
- Dynamic changes of hepatic vein Doppler velocities predict preload responsiveness in mechanically ventilated critically ill patients.Intensive care medicine experimental · 2024Article
- Measurement error of pulse pressure variation.Journal of clinical monitoring and computing · 2024Article
- Supine transfer test-induced changes in cardiac index predict fluid responsiveness in patients without intra-abdominal hypertension.BMC anesthesiology · 2023Article
- Ability of the Analgesia Nociception Index variations to identify a response to a volume expansion of 250 mL of crystalloids in the operating room (REVANI): a prospective observational study.BMC anesthesiology · 2023Observational
- Non-invasive continuous cardiac output monitoring in thoracic cancer surgery: A comparative study between calibrated pulse contour analysis and chest bioreactance.European journal of anaesthesiology and intensive care · 2022Article
- Tidal volume challenge to predict preload responsiveness in patients with acute respiratory distress syndrome under prone position.Critical care (London, England) · 2022Observational
- Prediction of fluid responsiveness. What's new?Annals of intensive care · 2022Review
- Management of sepsis and septic shock in the emergency department.Internal and emergency medicine · 2021Review
- Bioreactance reliably detects preload responsiveness by the end-expiratory occlusion test when averaging and refresh times are shortened.Annals of intensive care · 2021Article
- Norepinephrine potentiates the efficacy of volume expansion on mean systemic pressure in septic shock.Critical care (London, England) · 2021Article
- Evaluation of radial artery pulse pressure effects on detection of stroke volume changes after volume loading maneuvers in cardiac surgical patients.Annals of translational medicine · 2020Article
- Prediction of fluid responsiveness in spontaneously breathing patients.Annals of translational medicine · 2020Review
- The end-expiratory occlusion test for detecting preload responsiveness: a systematic review and meta-analysis.Annals of intensive care · 2020Article
- Observational
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMany maneuvers assessing fluid responsiveness (minifluid challenge, lung recruitment maneuver, end-expiratory occlusion test, passive leg raising) are considered as positive when small variations in cardiac index, stroke volume index, stroke volume variation or pulse pressure variation occur. Pulse contour analysis allows continuous and real-time cardiac index, stroke volume, stroke volume variation and pulse pressure variation estimations. To use these maneuvers with pulse contour analysis, the knowledge of the minimal change that needs to be measured by a device to recognize a real change (least significant change) has to be studied. The aim of this study was to evaluate the least significant change of cardiac index, stroke volume index, stroke volume variation and pulse pressure variation obtained using pulse contour analysis (ProAQT
methodsIn this observational study, we included 50 mechanically ventilated patients undergoing neurosurgery in the operating room. Cardiac index, stroke volume index, pulse pressure variation and stroke volume variation obtained using ProAQT
resultsLeast significant changes statistically differed over time for cardiac index, stroke volume index, pulse pressure variation and stroke volume variation (p < 0.001). Least significant changes ranged from 1.3 to 0.7% for cardiac index, from 1.3 to 0.8% for stroke volume index, from 10 to 4.9% for pulse pressure variation and from 10.8 to 4.3% for stroke volume variation.
conclusionTo conclude, the present study suggests that pulse contour analysis is able to detect rapid and small changes in cardiac index and stroke volume index, but the interpretation of rapid and small changes of pulse pressure variation and stroke volume variation must be done with caution.
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