ReviewInternational ophthalmology2020
Ocular abnormalities in beta thalassemia patients: prevalence, impact, and management strategies.
Review in International ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Ocular Complications in Patients With Transfusion-Dependent Beta-Thalassemia Receiving Deferasirox: A Cross-Sectional Study.Health science reports · 2026Article
- The impact of systemic iron overload on retinal and choroidal microcirculation in transfusion-dependent beta-thalassemia patients.BMC ophthalmology · 2026Article
- Factors affecting color vision: a systematic review.International journal of ophthalmology · 2026Review
- Spectrum of Ophthalmic Manifestations in Patients With Transfusion-Dependent Thalassemia.Cureus · 2025Article
- Optical coherence tomography findings in beta-thalassemia major: a systematic review and Meta-analysis.International journal of ophthalmology · 2025Article
- Macular microvascular changes in children with transfusion-dependent beta-thalassemia.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021Observational
- Novel retinal findings in β-thalassemia major: older age and higher ferritin level as the risk factors.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021Article
- Do We Store Packed Red Blood Cells under "Quasi-Diabetic" Conditions?Biomolecules · 2021Review
- Evaluation of radial peripapillary capillary density in patients with newly diagnosed iron deficiency anemia.International ophthalmology · 2021Article
- Ocular findings in patients with transfusion-dependent β-thalassemia in southern Iran.BMC ophthalmology · 2020Article
- Ocular biometry, anterior chamber morphometry, and their relationship with serum ferritin levels in children with beta thalassemia major.Therapeutic advances in ophthalmologyArticle
- A very unusual case report: Retinal neovascularization and tractional retinal detachment in a patient with thalassemia minor.Taiwan journal of ophthalmologyArticle
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBeta thalassemia (β-thalassemia) is a hereditary disease caused by defective globin synthesis and can be classified into three categories of minor (β-TMi), intermedia (β-TI), and major (β-TM) thalassemia. The aim of our study is to investigate the effects of β-thalassemia and its treatment methods on different parts of the eye and how early-diagnostic methods of ocular complications in this disorder would prevent further ocular complications in these patients by immediate treatment and diet change.
methodsWe developed a search strategy using a combination of the words Beta thalassemia, Ocular abnormalities, Iron overload, chelation therapy to identify all articles from PubMed, Web of Science, Scopus, and Google Scholar up to December 2018. To find more articles and to ensure that databases were thoroughly searched, the reference lists of selected articles were also reviewed.
resultsComplications such as retinopathy, crystalline lens opacification, color vision deficiency, nyctalopia, depressed visual field, reduced visual acuity, reduced contrast sensitivity, amplitude reduction in a-wave and b-wave in Electroretinography (ERG), and decrease in the Arden ratio in Electrooculography (EOG) have all been reported in β-thalassemia patients undergoing chelation therapy.
conclusionOcular problems due to β-thalassemia may be a result of anemia, iron overload in the body tissue, side effects of iron chelators, and the complications of orbital bone marrow expansion.
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Registered trials
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