ArticleLangenbeck's archives of surgery2019
Prognostic factors and patterns of recurrence after emergency management for obstructing colon cancer: multivariate analysis from a series of 2120 patients.
Article in Langenbeck's archives of surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Short-term and three-year long-term outcomes of laparoscopic surgery versus open surgery for obstructive colorectal cancer following self-expandable metallic stent placement: a meta-analysis.Surgical endoscopy · 2024Pooled it
- Colonic stent as a bridge to surgery versus emergency resection for right-sided malignant large bowel obstruction: a meta-analysis.Surgical endoscopy · 2022Pooled it
- Lipid profile-based prognostic nomograms for obstructive colorectal cancer: multi-cohort development and validation.Frontiers in medicine · 2026Article
- Prognostic determinants in surgical critial patients undergoing emergency surgery for Stage III or higher colorectal cancer.Langenbeck's archives of surgery · 2025Article
- Comparison of early and long-term clinical outcomes in obstructed proximal and distal colon cancers undergoing emergent surgery.Przeglad gastroenterologiczny · 2025Article
- Large Bowel Obstruction: Etiologies, Diagnosis, and Management.Clinics in colon and rectal surgery · 2024Review
- Oncologic investigation of the interval from stent placement to surgery in patients with obstructive colorectal cancer.Surgery today · 2024Article
- Management of obstructed colorectal carcinoma in an emergency setting: An update.World journal of gastrointestinal oncology · 2024Review
- Surgical treatment and overall survival in patients with right-sided obstructing colon cancer-a nationwide retrospective cohort study.International journal of colorectal disease · 2023Article
- A Review of Colonoscopy in Intestinal Diseases.Diagnostics (Basel, Switzerland) · 2023Review
- Article
- Which prognostic factors are important for long-term outcomes in symptomatic obstructive colon cancer? A multi-institutional retrospective cohort study.Journal of minimally invasive surgery · 2021Article
- Malignant Large Bowel Obstruction.Clinics in colon and rectal surgery · 2021Review
- Evaluation of prognostic factors and clinicopathological patterns of recurrence after curative surgery for colorectal cancer.World journal of gastrointestinal surgery · 2021Article
- The prognostic value of combined tumor markers and systemic immune-inflammation index in colorectal cancer patients.Langenbeck's archives of surgery · 2020Article
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAt equal TNM stage, obstructing colon cancer (OCC) is associated with worse prognosis in comparison with uncomplicated cancer. Our aim was to identify prognostic factors of overall (OS) and disease-free survival (DFS) in patients treated for OCC.
methodsFrom 2000 to 2015, 2325 patients were treated for OCC in French surgical centers, members of the French National Surgical Association (AFC). Patients with palliative management were excluded. The main endpoints were OS and DFS. A multivariate analysis, using Cox proportional hazards regression model, was performed to determine independent prognostic factors.
resultsThe cohort included 2120 patients. The median of follow-up was 13.2 months. In multivariate analysis, age > 75 years, ASA score ≥ 3, ECOG score ≥ 3, right-sided colon cancer, presence of synchronous metastases, anastomotic leakage, and absence of adjuvant chemotherapy were independent OS factors. Age > 75 years, ASA score ≥ 3, right-sided colon cancer, presence of synchronous metastases, and absence of postoperative chemotherapy were independent factors of poor OS after exclusion of patients who died postoperatively. Age ≥ 75 years, ASA score ≥ 3, ECOG score ≥ 3, right-sided colon cancer, lymph node involvement, presence of vascular, lymphatic or perineural invasion, less than 12 harvested lymph nodes, and absence of adjuvant chemotherapy were independent DFS factors.
conclusionsManagement of OCC should take into account prognostic factors related to the patient (age, comorbidities), tumor location, and tumor stage. Adjuvant chemotherapy administration plays an important role. For patients undergoing initial defunctionning stoma, neoadjuvant chemotherapy could be an option to improve prognosis.
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