Evidence map›Paper›PMID 31602484›Full record

ArticleNucleic acids research2020

VDJbase: an adaptive immune receptor genotype and haplotype database.

Aviv Omer, Or Shemesh, Ayelet Peres, Pazit Polak, Adrian J Shepherd, Corey T Watson, Scott D Boyd, Andrew M Collins, William Lees, Gur Yaari

Abstract read
In one paragraph

Article in Nucleic acids research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed.

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  8. Genomic analysis of Canadian children with food allergies points to the immunoglobulin heavy chain gene locus.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Aviv OmerBioengineering, Faculty of Engineering, Bar-Ilan University, Ramat Gan 5290002, Israel.
Or ShemeshBioengineering, Faculty of Engineering, Bar-Ilan University, Ramat Gan 5290002, Israel.
Ayelet PeresBioengineering, Faculty of Engineering, Bar-Ilan University, Ramat Gan 5290002, Israel.
Pazit PolakBioengineering, Faculty of Engineering, Bar-Ilan University, Ramat Gan 5290002, Israel.
Adrian J ShepherdInstitute of Structural and Molecular Biology, Birkbeck, University of London, London, UK.
Corey T WatsonUniversity of Louisville School of Medicine, Biochemistry and Molecular Genetics, Louisville, KY 40292, USA.
Scott D BoydDepartment of Pathology, Stanford University, Stanford, CA 94305, USA.
Andrew M CollinsSchool of Biotechnology and Biomolecular Sciences, University of NSW, Kensington, Sydney, NSW 2052, Australia.
William LeesInstitute of Structural and Molecular Biology, Birkbeck, University of London, London, UK.
Gur YaariBioengineering, Faculty of Engineering, Bar-Ilan University, Ramat Gan 5290002, Israel.

Funding

Effects of aging on primary and secondary vaccine responses in a 15-year longitudinal cohortR01AI130398 · NIAID · STANFORD UNIVERSITY · PI BOYD, SCOTT DEXTER · 2017 to 2021
$4.0M
FUNCTIONAL ANALYSIS OF PATHOGENIC AND PROTECTIVE PEANUT ALLERGEN-SPECIFIC HUMAN ANTIBODIESR01AI125567 · NIAID · STANFORD UNIVERSITY · PI BOYD, SCOTT DEXTER · 2017 to 2022
$2.6M
Storage and recall of human B cell memory of influenza over tissues and timeR01AI127877 · NIAID · STANFORD UNIVERSITY · PI BOYD, SCOTT DEXTER · 2017 to 2021
$2.0M
NIAID NIH HHS R01 AI125567NIAID NIH HHS R01 AI127877NIAID NIH HHS R01 AI130398
6 · The paper itself

Abstract

VDJbase is a publicly available database that offers easy searching of data describing the complete sets of gene sequences (genotypes and haplotypes) inferred from adaptive immune receptor repertoire sequencing datasets. VDJbase is designed to act as a resource that will allow the scientific community to explore the genetic variability of the immunoglobulin (Ig) and T cell receptor (TR) gene loci. It can also assist in the investigation of Ig- and TR-related genetic predispositions to diseases. Our database includes web-based query and online tools to assist in visualization and analysis of the genotype and haplotype data. It enables users to detect those alleles and genes that are significantly over-represented in a particular population, in terms of genotype, haplotype and gene expression. The database website can be freely accessed at https://www.vdjbase.org/, and no login is required. The data and code use creative common licenses and are freely downloadable from https://bitbucket.org/account/user/yaarilab/projects/GPHP.

Indexed as

Databases, GeneticGenotypeHaplotypesV(D)J RecombinationComputational BiologyHumansMolecular Sequence AnnotationReceptors, Antigen, B-CellReceptors, Antigen, T-CellReceptors, ImmunologicSoftwareSoftware DesignWeb BrowserWorkflowReceptors, Antigen, B-CellReceptors, Antigen, T-CellReceptors, Immunologic

Identifiers

PMID31602484
PMCPMC6943044

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.