ArticleCerebral cortex (New York, N.Y. : 1991)2020
Quantitative In vivo MRI Assessment of Structural Asymmetries and Sexual Dimorphism of Transient Fetal Compartments in the Human Brain.
Article in Cerebral cortex (New York, N.Y. : 1991), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 58 citations in OpenAlex.
- Typical development of the human fetal subplate: Regional heterogeneity, growth, and asymmetry assessed by in vivo T2-weighted MRI.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Mapping brain growth and sex differences across prenatal to postnatal development.Scientific reports · 2026Article
- Assessment of resting state structural-functional relationships in perisylvian region during the early weeks after birth.Brain structure & function · 2025Article
- Typical development of the human fetal subplate: regional heterogeneity, growth, and asymmetry assessed by in vivo T2-weighted MRI.bioRxiv : the preprint server for biology · 2025Article
- Sulcal pits as potential markers of early sex-related human brain differences in healthy adults.Biology of sex differences · 2025Article
- Large-scale analysis of structural brain asymmetries during neurodevelopment: Associations with age and sex in 4265 children and adolescents.Human brain mapping · 2024Article
- Advances in Fetal Brain Imaging.Magnetic resonance imaging clinics of North America · 2024Review
- Longitudinal MRI of the developing ferret brain reveals regional variations in timing and rate of growth.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Divergent growth of the transient brain compartments in fetuses with nonsyndromic isolated clefts involving the primary and secondary palate.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Maternal anxiety during pregnancy is associated with weaker prefrontal functional connectivity in adult offspring.Brain imaging and behavior · 2023Article
- Normative spatiotemporal fetal brain maturation with satisfactory development at 2 years.Nature · 2023Article
- Atypical fetal brain development in fetuses with non-syndromic isolated musculoskeletal birth defects (niMSBDs).Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Development of cortical folds in the human brain: An attempt to review biological hypotheses, early neuroimaging investigations and functional correlates.Developmental cognitive neuroscience · 2023Review
- Fetal development of functional thalamocortical and cortico-cortical connectivity.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Robust sex differences in functional brain connectivity are present in utero.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Fetal behavior during MRI changes with age and relates to network dynamics.Human brain mapping · 2023Article
- Gestational age-related changes in the fetal functional connectome: in utero evidence for the global signal.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Abnormal development of transient fetal zones in mild isolated fetal ventriculomegaly.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Characterization of dynamic patterns of human fetal to neonatal brain asymmetry with deformation-based morphometry.Frontiers in neuroscience · 2023Article
- Diffusion tensor imaging reveals sex differences in pain sensitivity of rats.Frontiers in molecular neuroscience · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
Abstract
Structural asymmetries and sexual dimorphism of the human cerebral cortex have been identified in newborns, infants, children, adolescents, and adults. Some of these findings were linked with cognitive and neuropsychiatric disorders, which have roots in altered prenatal brain development. However, little is known about structural asymmetries or sexual dimorphism of transient fetal compartments that arise in utero. Thus, we aimed to identify structural asymmetries and sexual dimorphism in the volume of transient fetal compartments (cortical plate [CP] and subplate [SP]) across 22 regions. For this purpose, we used in vivo structural T2-weighted MRIs of 42 healthy fetuses (16.43-36.86 gestational weeks old, 15 females). We found significant leftward asymmetry in the volume of the CP and SP in the inferior frontal gyrus. The orbitofrontal cortex showed significant rightward asymmetry in the volume of CP merged with SP. Males had significantly larger volumes in regions belonging to limbic, occipital, and frontal lobes, which were driven by a significantly larger SP. Lastly, we did not observe sexual dimorphism in the growth trajectories of the CP or SP. In conclusion, these results support the hypothesis that structural asymmetries and sexual dimorphism in relative volumes of cortical regions are present during prenatal brain development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.