ArticleNature metabolism2019
4-Methylumbelliferone improves the thermogenic capacity of brown adipose tissue.
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Article in Nature metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
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Who cites it
25 citing papers in PubMed, 40 citations in OpenAlex.
- Randomised, placebo-controlled trial of oral hymecromone in adults with pulmonary hypertension.Thorax · 2025Trial
- 4-methylumbelliferone attenuates amyloid pathology and learning deficits in the APP/PS1 mouse model.bioRxiv : the preprint server for biology · 2026Article
- Gabpα-Pparγ Complex Determines Glycolytic Capacity and Lactic Acid Homeostasis in Brown Fat.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Therapeutic targeting of the AMPK-Has1 complex formation ameliorates metabolic dysfunction-associated steatohepatitis in mice.Theranostics · 2026Article
- Impairment of Hyaluronan-Related Glycocalyx Inhibits Macropinocytosis in Cancer Cells via p21 Upregulation.Biomacromolecules · 2025Article
- Functional Complexity of Thermogenic Adipose Tissue: From Thermogenesis to Metabolic and Fibroinflammatory Crosstalk.International journal of molecular sciences · 2025Review
- ECM remodeling in hypothyroidism-associated MAFLD: mechanisms, clinical relevance, and therapeutic targets.Frontiers in immunology · 2025Review
- Beneficial Actions of 4-Methylumbelliferone in Type 1 Diabetes by Promoting β Cell Renewal and Inhibiting Dedifferentiation.Biomedicines · 2024Article
- Article
- Magnetic resonance reveals early lipid deposition in murine prediabetes as predictive marker for cardiovascular injury.Npj imaging · 2024Article
- The thrombin receptor PAR4 supports visceral adipose tissue inflammation.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Complex II ambiguities-FADHThe Journal of biological chemistry · 2024Review
- Exploring opportunities for drug repurposing and precision medicine in cannabis use disorder using genetics.Addiction biology · 2023Article
- SYSTEMI - systemic organ communication in STEMI: design and rationale of a cohort study of patients with ST-segment elevation myocardial infarction.BMC cardiovascular disorders · 2023Article
- 4-Methylumbelliferone Targets Revealed by Public Data Analysis and Liver Transcriptome Sequencing.International journal of molecular sciences · 2023Article
- Linsitinib, an IGF-1R inhibitor, attenuates disease development and progression in a model of thyroid eye disease.Frontiers in endocrinology · 2023Article
- Small fragments of hyaluronan are increased in individuals with obesity and contribute to low-grade inflammation through TLR-mediated activation of innate immune cells.International journal of obesity (2005) · 2022Article
- Crosstalk between CD4 T cells and synovial fibroblasts from human arthritic joints promotes hyaluronan-dependent leukocyte adhesion and inflammatory cytokine expression in vitro.Matrix biology plus · 2022Article
- Many Ways to Rome: Exercise, Cold Exposure and Diet-Do They All Affect BAT Activation and WAT Browning in the Same Manner?International journal of molecular sciences · 2022Review
- Endogenously-Produced Hyaluronan and Its Potential to Regulate the Development of Peritoneal Adhesions.Biomolecules · 2021Review
Corrections and comments
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Authors and funding
25 authors at 9 institutions in 5 countries.
Maria GrandochInstitute of Pharmacology and Clinical Pharmacology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Ulrich FlögelExperimental Cardiovascular Imaging, Molecular Cardiology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Sam VirtueMRC Metabolic Diseases Unit, Metabolic Research Laboratories, University of Cambridge, Cambridge, United Kingdom.
Julia K MaierInstitute of Pharmacology and Clinical Pharmacology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Tomas JelenikInstitute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at the Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Christina KohlmorgenInstitute of Pharmacology and Clinical Pharmacology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Kathrin FeldmannInstitute of Pharmacology and Clinical Pharmacology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Yanina OstendorfInstitute of Pharmacology and Clinical Pharmacology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Tamara R CastañedaGerman Center for Diabetes Research (DZD e.V.), München-Neuherberg, Germany.
Zhou ZhouGerman Center for Diabetes Research (DZD e.V.), München-Neuherberg, Germany.
Yu YamaguchiHuman Genetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Emmani B M NascimentoDepartment of Nutrition and Movement Sciences, Maastricht Medical Centre, NUTRIM School of Nutrition and Translational Research in Metabolism, The Netherlands.
Vivekananda G SunkariDivision of Infectious Diseases and Geographic Medicine, Dept. of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Christine GoyInstitute for Clinical Chemistry, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Martina KinzigInstitute for Biomedical and Pharmaceutical Research, Nürnberg-Heroldsberg, Germany.
Fritz SörgelInstitute for Biomedical and Pharmaceutical Research, Nürnberg-Heroldsberg, Germany.
Paul L BollykyDivision of Infectious Diseases and Geographic Medicine, Dept. of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Patrick SchrauwenDepartment of Nutrition and Movement Sciences, Maastricht Medical Centre, NUTRIM School of Nutrition and Translational Research in Metabolism, The Netherlands.
Hadi Al-HasaniGerman Center for Diabetes Research (DZD e.V.), München-Neuherberg, Germany.
Michael RodenInstitute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at the Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Susanne KeipertGerman Center for Diabetes Research (DZD e.V.), München-Neuherberg, Germany.
Antonio Vidal-PuigMRC Metabolic Diseases Unit, Metabolic Research Laboratories, University of Cambridge, Cambridge, United Kingdom.
Martin JastrochGerman Center for Diabetes Research (DZD e.V.), München-Neuherberg, Germany.
Judith HaendelerInstitute for Clinical Chemistry, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Jens W FischerInstitute of Pharmacology and Clinical Pharmacology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Heinrich Heine University Düsseldorf · DEDeutsches Diabetes-Zentrum e.V. · DEInstitute for Biomedical and Pharmaceutical Research · DEMaastricht University Medical Centre · NLStanford Medicine · USStockholm University · SEUniversity of Cambridge · GBLeibniz Institute of Environmental Medicine · DESanford Burnham Prebys Medical Discovery Institute · US
Funding
Tissue Cytokine Sequestration and Immune Regulation in AutoimmunityU01AI101984 · NIAID · STANFORD UNIVERSITY · PI BOLLYKY, PAUL L · 2012 to 2021
$5.0MLymph Node Extracellular Matrix in Antigen Presentation and Immune RegulationR01DK096087 · NIDDK · STANFORD UNIVERSITY · PI BOLLYKY, PAUL L · 2012 to 2021
$3.4MThe Development of 4-methylumbelliferone Pro-drugs to Prevent Autoimmune DiabetesR01DK114174 · NIDDK · STANFORD UNIVERSITY · PI BOLLYKY, PAUL L · 2018 to 2020
$1.3MHeparanase and Regulatory T cell Stability and FunctionR21AI133240 · NIAID · STANFORD UNIVERSITY · PI BOLLYKY, PAUL L · 2018 to 2019
$438kBritish Heart Foundation RG/12/13/29853British Heart Foundation RG/18/7/33636Medical Research Council G0600717Medical Research Council G0802051Medical Research Council MC_UU_00014/2Medical Research Council MC_UU_00014/5Medical Research Council MC_UU_12012/2Medical Research Council MC_UU_12012/5NIAID NIH HHS R21 AI133240NIAID NIH HHS U01 AI101984NIDDK NIH HHS R01 DK096087NIDDK NIH HHS R01 DK114174
Abstract
Therapeutic increase of brown adipose tissue (BAT) thermogenesis is of great interest as BAT activation counteracts obesity and insulin resistance. Hyaluronan (HA) is a glycosaminoglycan, found in the extracellular matrix, which is synthesized by HA synthases (Has1/Has2/Has3) from sugar precursors and accumulates in diabetic conditions. Its synthesis can be inhibited by the small molecule 4-methylumbelliferone (4-MU). Here, we show that the inhibition of HA-synthesis by 4-MU or genetic deletion of
Indexed as
Adipose Tissue, BrownAnimalsEnergy MetabolismHymecromoneInsulin ResistanceMaleMiceMice, Inbred C57BLThermogenesisHymecromone
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.