Evidence map›Paper›PMID 31602389›Full record

ReviewVisceral medicine2019

Molecular Approaches to Metastatic Colorectal Cancer: Better Diagnosis - Better Treatment?

Thomas Seufferlein, Carolina Simões, Fernando Kude, Thomas J Ettrich

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Visceral medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04863768 (Molecular Profiling of Colorectal Cancer), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04863768 unknown statusnot on this map

Molecular Profiling of Colorectal Cancer: A Translational Research Study With a Next Generation Sequencing Panel.

TypeobservationalSponsorHellenic Cooperative Oncology GroupRan2006 to 2022Enrolled300ConditionsColorectal Cancer, Colon Cancer, Colon AdenocarcinomaArmsGene panel
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Thomas SeufferleinDepartment of Internal Medicine I, Ulm University Hospital, Ulm, Germany.
Carolina SimõesHospital de Santa Maria, Centro Hospitalar Universitario Lisboa Norte, Lisbon, Portugal.
Fernando KudePathology, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil.
Thomas J EttrichDepartment of Internal Medicine I, Ulm University Hospital, Ulm, Germany.
University Hospital Ulm · DEHospital de Santa Maria · PTUniversidade Federal de Ciências da Saúde de Porto Alegre · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Molecular diagnostics of metastatic colorectal cancer (mCRC) are coming of age. Whereas for many years RAS mutations were the only relevant molecular alterations examined in mCRC, nowadays the BRAF, HER2, and microsatellite instability status of a given tumor is gaining importance, since it has not only prognostic relevance but opens new avenues for therapeutic approaches. This review summarizes the recent advances in molecular approaches to mCRC and their therapeutic consequences and discusses novel approaches for molecular diagnostics in mCRC.

Indexed as

Colorectal cancerMolecular approachPersonalized medicine

Identifiers

PMID31602389
PMCPMC6738174
OpenAlexW2959323536

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.