Evidence map›Paper›PMID 31602373›Full record

ArticleGastrointestinal tumors2019

Detection of Novel Fusion Transcript VTI1A-CFAP46 in Hepatocellular Carcinoma.

Shunichi Tsuge, Behnam Saberi, Yulan Cheng, Zhixiong Wang, Amy Kim, Harry Luu, John M Abraham, Maria D Ybanez, James P Hamilton, Florin M Selaru and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gastrointestinal tumors, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 2 countries.

Shunichi TsugeDivision of Gastroenterology and Hepatology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Behnam SaberiDivision of Gastroenterology and Hepatology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Yulan ChengDivision of Gastroenterology and Hepatology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Zhixiong WangDivision of Gastroenterology and Hepatology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Amy KimDivision of Gastroenterology and Hepatology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Harry LuuDivision of Gastroenterology and Hepatology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
John M AbrahamDivision of Gastroenterology and Hepatology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Maria D YbanezDepartment of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
James P HamiltonDivision of Gastroenterology and Hepatology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Florin M SelaruDivision of Gastroenterology and Hepatology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Carlos Villacorta-MartinDivision of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Felix SchlesingerIllumina, San Diego, California, USA.
Benjamin PhilosopheDepartment of Transplant Surgery, The Johns Hopkins University, Baltimore, Maryland, USA.
Andrew M CameronDepartment of Transplant Surgery, The Johns Hopkins University, Baltimore, Maryland, USA.
Qingfeng ZhuDepartment of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Robert AndersDepartment of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Ahmet GurakarDivision of Gastroenterology and Hepatology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Stephen J MeltzerDivision of Gastroenterology and Hepatology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Johns Hopkins University · USJohns Hopkins Medicine · USIcahn School of Medicine at Mount Sinai · USIllumina (United States) · USThe First Affiliated Hospital, Sun Yat-sen University · CN

Funding

Translational Research Enhancement CoreP30DK089502 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI ZACHOS, NICHOLAS CONSTANTINE · 2011 to 2020
$12.0M
NIDDK NIH HHS P30 DK089502
6 · The paper itself

Abstract

backgroundHepatocellular carcinoma (HCC) is now the second-highest cause of cancer death worldwide. Recent studies have discovered a wide range of somatic mutations in HCC. These mutations involve various vital signaling pathways such as: Wnt/

methodsTo identify novel fusion transcripts in HCC, in the first phase of our study, we performed targeted RNA sequencing (in HCC and paired non-HCC tissues) on 6 patients with a diagnosis of HCC undergoing liver transplantation.

resultsAs a result of these studies, we discovered the novel fusion transcript, VTI1A-CFAP46. In the second phase of our study, we measured the expression of wild-type VTI1A in 21 HCC specimens, which showed that 10 of 21 exhibited upregulation of wild-type VTI1A in their tumors. VTI1A (Vesicle Transport via Interaction with t-SNARE homolog 1A) is a member of the Soluble N-ethylmaleimide-Sensitive Factor (NSF) attachment protein receptor (SNARE) gene family, which is essential for membrane trafficking and function in endocytosis, autophagy, and Golgi transport. Notably, it is known that autophagy is involved in HCC.

conclusionsThe link between novel fusion transcript VTI1A-CFAP46 and autophagy as a potential therapeutic target in HCC patients deserves further investigation. Moreover, this study shows that fusion transcripts are worthy of additional exploration in HCC.

Indexed as

Fusion transcriptHepatocellular carcinomaHepatomaLiver transplantationRNA sequencing

Identifiers

PMID31602373
PMCPMC6738276
OpenAlexW2937438478

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.