Evidence map›Paper›PMID 31602357›Full record

ArticleColloid and interface science communications2019

Inverse-micelle synthesis of doxorubicin-loaded alginate/chitosan nanoparticles and

Justin G Rosch, Hayden Winter, Allison N DuRoss, Gaurav Sahay, Conroy Sun

Abstract read
In one paragraph

Article in Colloid and interface science communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Natural carrier systems in cancer vaccines and immunotherapy.Human vaccines & immunotherapeutics · 2025
    Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Chitosan Nanoparticles as Oral Drug Carriers.International journal of molecular sciences · 2023
    Review
  8. Review
  9. Review
  10. Nanocarriers for anticancer drugs: Challenges and perspectives.Saudi journal of biological sciences · 2022
    Review
  11. Review
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Justin G RoschDepartment of Pharmaceutical Science, Oregon State University, 2730 SW Moody Ave, Portland, OR, 97201, USA.
Hayden WinterDepartment of Chemistry, Portland State University, 1719 SW 10th Ave, Portland, OR, 97201, USA.
Allison N DuRossDepartment of Pharmaceutical Science, Oregon State University, 2730 SW Moody Ave, Portland, OR, 97201, USA.
Gaurav SahayDepartment of Pharmaceutical Science, Oregon State University, 2730 SW Moody Ave, Portland, OR, 97201, USA.
Conroy SunDepartment of Pharmaceutical Science, Oregon State University, 2730 SW Moody Ave, Portland, OR, 97201, USA.

Funding

Synergistic combination of nanotechnology and radiation in medicineR35GM119839 · NIGMS · OREGON STATE UNIVERSITY · PI SUN, CONROY GHIN CHEE · 2016 to 2020
$1.8M
Mechanisms of Intracellular trafficking and endosomal escape of nanoparticles for mRNA deliveryR15EB021581 · NIBIB · OREGON STATE UNIVERSITY · PI SAHAY, GAURAV · 2017 to 2017
$441k
NIBIB NIH HHS R15 EB021581NIGMS NIH HHS R35 GM119839
6 · The paper itself

Abstract

Naturally-derived polysaccharides, such as alginate and chitosan, can be assembled to form nanocarriers for the delivery of therapeutic agents. Here we exploit the electrostatic complexation of alginate/chitosan in a water-in-oil (w/o) emulsion process to produce doxorubicin (DOX)-loaded nanoparticles (~80 nm) with exceptional spherical morphology and uniformity. This robust synthetic route utilizes an aqueous phase dispersed in a cyclohexane/dodecylamine organic phase and is capable of encapsulating DOX in the nanoparticle solution. The uptake and efficacy of this novel formulation was evaluated in a murine breast cancer cell line, 4T1, with comparable 72 h IC

Indexed as

alginatebreast cancercell viabilitychitosandoxorubicin

Identifiers

PMID31602357
PMCPMC6786499

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.