Evidence map›Paper›PMID 31602344›Full record

ArticleTranslational vision science & technology2019

Comparison of Fundus-Guided Microperimetry and Multifocal Electroretinography for Evaluating Hydroxychloroquine Maculopathy.

Husam Alghanem, Tapas R Padhi, Adrienne Chen, Leslie M Niziol, Maria Fernanda Abalem, Natalie Dakki, Timothy Steffens, Chris Andrews, David C Musch, K Thiran Jayasundera and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational vision science & technology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Husam AlghanemDepartment of Ophthalmology and Visual Sciences, Medical School, University of Michigan, Ann Arbor, MI, USA.
Tapas R PadhiDepartment of Ophthalmology and Visual Sciences, Medical School, University of Michigan, Ann Arbor, MI, USA.
Adrienne ChenDepartment of Ophthalmology and Visual Sciences, Medical School, University of Michigan, Ann Arbor, MI, USA.
Leslie M NiziolDepartment of Ophthalmology and Visual Sciences, Medical School, University of Michigan, Ann Arbor, MI, USA.
Maria Fernanda AbalemDepartment of Ophthalmology and Visual Sciences, Medical School, University of Michigan, Ann Arbor, MI, USA.
Natalie DakkiDepartment of Ophthalmology and Visual Sciences, Medical School, University of Michigan, Ann Arbor, MI, USA.
Timothy SteffensDepartment of Ophthalmology and Visual Sciences, Medical School, University of Michigan, Ann Arbor, MI, USA.
Chris AndrewsDepartment of Ophthalmology and Visual Sciences, Medical School, University of Michigan, Ann Arbor, MI, USA.
David C MuschDepartment of Ophthalmology and Visual Sciences, Medical School, University of Michigan, Ann Arbor, MI, USA.
K Thiran JayasunderaDepartment of Ophthalmology and Visual Sciences, Medical School, University of Michigan, Ann Arbor, MI, USA.
Naheed W KhanDepartment of Ophthalmology and Visual Sciences, Medical School, University of Michigan, Ann Arbor, MI, USA.
University of Michigan–Ann Arbor · US

Funding

VIVARIUM MODULEP30EY007003 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI David Antonetti · 1987 to 2026
$17.6M
Targeted functional testing for retinal diseases based on patient reported outcomesK23EY026985 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JAYASUNDERA, KANISHKA THIRAN · 2016 to 2020
$1.2M
NEI NIH HHS K23 EY026985NEI NIH HHS P30 EY007003
6 · The paper itself

Abstract

purposeTo compare retinal function by using fundus-guided microperimetry (MP) and multifocal electroretinography (mfERG) for detecting hydroxychloroquine (HCQ) maculopathy.

methodsForty-six eyes of 25 patients referred to our clinical practice for HCQ maculopathy assessment and 3 groups of normal control subjects were evaluated by mfERG and MP. Macular structure was assessed using spectral-domain optical coherence tomography (SD-OCT). Ring ratios from the three innermost mERG rings were compared with average sensitivity of each MP ring at approximately equivalent distances from the fovea. HCQ toxicity was defined as an mfERG ring ratio or mean MP ring sensitivity >2 standard deviations below the normal mean. The sensitivity and specificity of MP to detect HCQ toxicity relative to mfERG were evaluated.

resultsMP rings MR2 and MR3 were positively correlated with corresponding mfERG ring ratios (r = 0.52,

conclusionsThe frequency of detection of HCQ toxicity with MP was greater than with mfERG. MP showed an overall good sensitivity and moderate specificity in detecting HCQ-induced functional deficits. TRANSLATIONAL RELEVANCE: Results from this study may allow clinicians to improve screening accuracy for HCQ toxicity by using the alternative modality of MP.

Indexed as

hydroxychloroquinemicroperimetrymultifocal electroretinographyPlaquenilring ratio

Identifiers

PMID31602344
PMCPMC6779178
OpenAlexW2974934275

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.