Evidence map›Paper›PMID 31602318›Full record

ArticleNPJ vaccines2019

Intranasal acellular pertussis vaccine provides mucosal immunity and protects mice from

Dylan T Boehm, M Allison Wolf, Jesse M Hall, Ting Y Wong, Emel Sen-Kilic, Hayden D Basinger, Sebastian A Dziadowicz, Maria de la Paz Gutierrez, Catherine B Blackwood, Shelby D Bradford and 5 more

Open access · goldAbstract read
In one paragraph

Article in NPJ vaccines, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Vaccines · 2026
    Review
  4. Review
  5. CD4+ T-cell immunity toDiscover immunity · 2026
    Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Opposing effects of acellular and whole cell pertussis vaccines onbioRxiv : the preprint server for biology · 2024
    Article
  14. Article
  15. Review
  16. Clinical microbiology reviews · 2023
    Review
  17. Pathogens and global health · 2023
    Review
  18. Frontiers in cellular and infection microbiology · 2023
    Article
  19. Generating enhanced mucosal immunity againstFrontiers in immunology · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

Dylan T Boehm1Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV USA.
M Allison Wolf1Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV USA.
Jesse M Hall1Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV USA.
Ting Y Wong1Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV USA.
Emel Sen-Kilic1Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV USA.ORCID 0000-0003-1583-2056
Hayden D Basinger3West Virginia University School of Medicine, Morgantown, WV USA.ORCID 0000-0002-0543-9149
Sebastian A Dziadowicz1Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV USA.ORCID 0000-0001-6277-9310
Maria de la Paz Gutierrez4Instituto de Biotecnología y Biología Molecular (IBBM)-CCT-CONICET-La Plata, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina.
Catherine B Blackwood1Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV USA.
Shelby D Bradford1Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV USA.ORCID 0000-0001-9794-8137
Katherine A Begley1Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV USA.
William T Witt1Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV USA.
Melinda E Varney1Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV USA.
Mariette Barbier1Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV USA.
F Heath Damron1Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, WV USA.
West Virginia University · USConsejo Nacional de Investigaciones Científicas y Técnicas · AR

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Sally Lynn Hodder · 2012 to 2026
$81.0M
WV INBRE: The Inhibitor of Growth Family Member 4 (ING4) inhibits L-Type Amino Acid Transporter 1 (LAT1) expression to suppress Breast CancerP20GM103434 · NIGMS · MARSHALL UNIVERSITY · PI GARY O RANKIN · 2012 to 2026
$61.1M
THE ROLE OF HEF1 PROTEIN IN INVASION OF METASTATIC BREAST CANCERP20RR016440 · NCRR · WEST VIRGINIA UNIVERSITY · PI CUFF, CHRISTOPHER F · 2001 to 2010
$22.8M
West Virginia Flow Cytometry Core FacilityP30GM103488 · NIGMS · WEST VIRGINIA UNIVERSITY · PI CUFF, CHRISTOPHER F · 2012 to 2016
$4.8M
Development of mucosal vaccines to protect against pertussisR01AI137155 · NIAID · WEST VIRGINIA UNIVERSITY · PI DAMRON, FREDRICK HEATH · 2019 to 2023
$2.9M
COBRE FOR SIGNAL TRANSDUCTION AND CANCER PHASE IIIP30RR032138 · NCRR · WEST VIRGINIA UNIVERSITY · PI GIBSON, LAURA F. · 2011 to 2011
$1.1M
Special Becton Dickinson Fortessa Flow CytometerS10OD016165 · OD · WEST VIRGINIA UNIVERSITY · PI CUFF, CHRISTOPHER F · 2013 to 2013
$384k
NCRR NIH HHS P20 RR016440NCRR NIH HHS P30 RR032138NIAID NIH HHS R01 AI137155NIGMS NIH HHS P20 GM103434NIGMS NIH HHS P30 GM103488NIGMS NIH HHS U54 GM104942NIH HHS S10 OD016165
6 · The paper itself

Abstract

Current acellular pertussis vaccines fall short of optimal protection against the human respiratory pathogen

Indexed as

AdjuvantsBacterial infectionImmunologyProtein vaccinesVaccines

Identifiers

PMID31602318
PMCPMC6776550
OpenAlexW2978155607

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.