Evidence map›Paper›PMID 31602292›Full record

ReviewF1000Research2019

Prefrontal cortex and cognitive control: new insights from human electrophysiology.

Alik S Widge, Sarah R Heilbronner, Benjamin Y Hayden

Abstract readReview
In one paragraph

Review in F1000Research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Neurostimulation to Improve Cognitive Flexibility.Current opinion in behavioral sciences · 2025
    Article
  7. Review
  8. Rational inattention in neural coding for economic choice.bioRxiv : the preprint server for biology · 2024
    Article
  9. Article
  10. Insula uses overlapping codes for emotion in self and others.bioRxiv : the preprint server for biology · 2024
    Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Journal of neural engineering · 2023
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alik S WidgeDepartment of Psychiatry, University of Minnesota, 3001 6th St SE, Minneapolis, MN, 55455, USA.
Sarah R HeilbronnerDepartment of Neuroscience, Center for Magnetic Resonance Research, and Center for Neuroengineering, University of Minnesota, 2021 6th St SE, Minneapolis, MN, 55455, USA.
Benjamin Y HaydenDepartment of Neuroscience, Center for Magnetic Resonance Research, and Center for Neuroengineering, University of Minnesota, 2021 6th St SE, Minneapolis, MN, 55455, USA.ORCID 0000-0002-7678-4281

Funding

NEURONAL BASIS OF PERSISTENCER01DA038615 · NIDA · UNIVERSITY OF ROCHESTER · PI HAYDEN, BENJAMIN Y · 2015 to 2024
$3.4M
Combined Cortical and Subcortical Recording and Stimulation as a Circuit-Oriented Treatment for Obsessive-Compulsive DisorderUH3NS100548 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI DOUGHERTY, DARIN D, WIDGE, ALIK S. · 2016 to 2024
$3.2M
Circuit Specific Electrical Brain StimulationR01MH119384 · NIMH · UNIVERSITY OF MINNESOTA · PI WIDGE, ALIK S. · 2019 to 2023
$2.4M
Revealing functional networks and circuits of the posteromedial cortex withanatomical connectivityR01MH118257 · NIMH · UNIVERSITY OF MINNESOTA · PI HEILBRONNER, SARAH RACHEL · 2019 to 2023
$1.9M
Measuring, Modeling, and Modulating Cross-Frequency CouplingR01EB026938 · NIBIB · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI EDEN, URI TZVI, KRAMER, MARK ALAN · 2018 to 2020
$1.0M
Engineering Plasticity and Connectivity in a Fear Regulation CircuitR21MH113103 · NIMH · UNIVERSITY OF MINNESOTA · PI WIDGE, ALIK S. · 2017 to 2018
$426k
NIBIB NIH HHS R01 EB026938NIDA NIH HHS R01 DA038615NIMH NIH HHS R01 MH118257NIMH NIH HHS R01 MH119384NIMH NIH HHS R21 MH113103NINDS NIH HHS UH3 NS100548
6 · The paper itself

Abstract

Cognitive control, the ability to regulate one's cognition and actions on the basis of over-riding goals, is impaired in many psychiatric conditions. Although control requires the coordinated function of several prefrontal cortical regions, it has been challenging to determine how they work together, in part because doing so requires simultaneous recordings from multiple regions. Here, we provide a précis of cognitive control and describe the beneficial consequences of recent advances in neurosurgical practice that make large-scale prefrontal cortical network recordings possible in humans. Such recordings implicate inter-regional theta (5-8 Hz) local field potential (LFP) synchrony as a key element in cognitive control. Major open questions include how theta might influence other oscillations within these networks, the precise timing of information flow between these regions, and how perturbations such as brain stimulation might demonstrate the causal role of LFP phenomena. We propose that an increased focus on human electrophysiology is essential for an understanding of the neural basis of cognitive control.

Indexed as

CognitionElectrophysiological PhenomenaHumansPrefrontal CortexcingulateCognitive controlConflictElectrophysiologyLocal field potential

Identifiers

PMID31602292
PMCPMC6768099

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.